KF/Al_2O_3催化反应精馏制备1-羟基-2-甲基-4-乙酰氧基-2-丁烯的研究  

Catalytic Synthesis of 1-Hydroxy-2-methyl-4-acetyloxy-2-butene with KF/Al_2O_3 by Reaction-distillation

作　　者：沈润溥[1] 孔识卫[2] 胡四平[2] 陈春峰[2] 张伯引[2] 王再中[2] 

机构地区：[1]绍兴文理学院化学化工学院,浙江绍兴312000 [2]浙江医药股份有限公司维生素厂,浙江新昌312000

出　　处：《江苏化工》2006年第17期16-18,共3页Jiangsu Chemical Industry

基　　金：绍兴市重点科研项目资助(20003109)

摘　　要：用KF/Al2O3催化1-甲酰氧基-2-甲基-4-乙酰氧基-2-丁烯进行酯交换反应制备1-羟基-2-甲基-4-乙酰氧基-2-丁烯,提高了反应选择性,并因采用反应精馏方式将反应时间缩短到5h,收率由77%提高到95%,后处理方便。1-Hydroxy-2-methyl-4- acetyloxy-2- butene was prepared by ester exchange reaction catalyzed by KF/Al2O3 from 1-formyloxy-2-methyl-4- acetyloxy-2-butene,the reaction selectivity is enhanced. Moreover,reaction time is shortcut,yield is raised and the process is simplified by the adoption of reaction-distillation method,which has a great industrial value. This new method demonstrates significance to the synthesis of similar compound via ester exchange reaction.

关 键 词：VA乙酸酯 1-羟基-2-甲基-4-乙酰氧基-2-丁烯 1-甲酰氧基-2-甲基-4-乙酰氧基-2-丁烯 酯交换反应 KF/AL2O3 反应精馏 

分 类 号：TQ223.14+2[化学工程—有机化工]