常频机械通气叠加高频振荡通气治疗新生儿重症呼吸衰竭  

The treatment of severe respiratory failure with SIMV plus HFOV in neonates

作　　者：赵幽燕[1] 平鹦[1] 徐英美[1] 吴玲[1] 

机构地区：[1]南京医科大学附属南京儿童医院新生儿医学中心,南京210008

出　　处：《南通大学学报（医学版）》2009年第4期239-241,共3页Journal of Nantong University(Medical sciences)

摘　　要：目的:评价常频机械通气叠加高频振荡通气(SIMV+HFOV)治疗新生儿重症呼吸衰竭的疗效。方法:将32例重症呼吸衰竭患儿予SIMV+HFOV模式机械通气治疗,观察0、2、6、12、24h患儿血气分析、呼吸力学参数、肺氧合功能指标的变化。结果:治疗2h后,动脉血氧分压(PaO2)及二氧化碳分压(PaCO2)即出现改变,6h后与开始上机时相比差异有统计学意义(P<0.01)。治疗6h后,肺顺应性C明显上升,MAP及气道阻力R下降,与开始上机时相比有差异(P<0.05),12h后差异有统计学意义(P<0.01)。肺氧合功能指标动脉-肺泡氧分压比值(a/APO2)及动脉氧分压与吸入氧浓度之比(PaO2/FiO2)治疗6h明显上升,氧合指数(OI)明显下降,与开始上机时相比差异均有统计学意义(P<0.01)。结论:SIMV+HFOV对新生儿重症呼吸衰竭,尤其是常频机械通气失败的患儿是一种行之有效的治疗方法。Objective:To evaluate the effectiveness of SIMV plus HFOV in treating severe respiratory failure in neonates. Methods:Blood gas analysis (BGA) ,respiratory physical measurement and oxygenation determination were compared before and 2,6,12,and 24 hours after the use of SIMV plus HFOV in 32 cases of neonates with severe respiratory failure. Results:After 2 hours of the treatment,the changes in PaO2 and PaCO2 appeared and after 6 hours they were very significantly different from initial ones. The increase of p...

关 键 词：呼吸衰竭 常频机械通气 高频振荡通气 新生儿 

分 类 号：R722.12[医药卫生—儿科]