哮喘家系的特应质性状遗传学分析  

Genetic analysis of the atopy of asthmatic pedigrees

作　　者：桂芹[1] 钱桂生[1] 王金平[1] 

机构地区：[1]第三军医大学新桥医院呼吸研究所

出　　处：《免疫学杂志》2009年第4期421-423,共3页Immunological Journal

摘　　要：目的对哮喘家系的特应质性状进行遗传分析。方法收集哮喘家系,对所有人进行血清IgE的测定、皮肤挑刺试验和支气管激发试验。结果①家系内哮喘病人和正常人SPT阳性有显著差异(P<0.05)。②血清总IgE增高个体SPT阳性百分数为76%,在正常个体SPT阳性百分数为53%,在两组之间有显著的差异(P<0.05)。③父母双方均为SPT阳性其子女SPT的阳性率为85.7%,父亲为SPT阳性而母亲正常其子女SPT的阳性率为81.8%,父亲正常母亲为SPT阳性其子女SPT的阳性率为63.6%,父母中任一方SPT阳性与父母SPT均正常其子女SPT阳性率比较有显著差异(P<0.05)。结论哮喘家系中病人特应质更明显;血清总IgE升高与SPT阳性有相关性。父母双方特应质对其子女特应质的影响最大。Objective To study,in genetics,the atopy of asthmatic pedigrees.Methods Asthmatic pedigrees were collected.Total IgE,skin prick test(SPT),and bronchial hyperresponsiveness of asthmatic pedigrees members were analyzed.Results 1) There was significant difference of SPT results between asthmatic patients and normal individuals(P<0.05).2) Higher level IgE and SPT positive subjects were 76% in asthmatic pedigrees,while normal persons SPT positive rate was 53%(P<0.05).3) Atopic rate of children with SPT positive ...

关 键 词：哮喘 特应症 皮肤挑刺试验 总IGE 

分 类 号：R562.25[医药卫生—呼吸系统]