高延展性聚合物水分散体的制备和特性研究  

Preparation and characterization of aqueous polymer dispersions with high flexibility for coating

作　　者：杨燕[1] 朱家壁[1] 郑春丽[1] 陈盛君[1] 

机构地区：[1]中国药科大学药物制剂研究所,南京210009

出　　处：《中国药科大学学报》2009年第4期310-315,共6页Journal of China Pharmaceutical University

基　　金：国家自然科学基金资助项目(No.30672549)~~

摘　　要：目的:制备新型高延展性聚合物水分散体,用于延展性缓释包衣,并对其理化性质和缓释包衣性能进行研究。方法:采用乳液聚合法,制备聚合物水分散体;研究其理化性质、成膜能力;考察其衣膜的机械性质和释药行为。结果:自制聚合物水分散体(甲基丙烯酸甲酯-丙烯酸乙酯,1∶2)具有适宜的理化性质、成膜能力和延展性,无需增塑剂和加热老化便能形成高延展性、低黏性的衣膜。制得的阿替洛尔缓释微丸4 h释药50%以上,10 h释药80%以上,释药行为在压片前后无明显变化。结论:自制高延展性聚合物水分散体适于延展性缓释包衣,可用于制备缓释微丸片。Aim:To prepare novel aqueous polymer dispersions with high flexibility for sustained-release coating and investigate their properties.Methods:The aqueous polymer dispersions were synthesized by the emulsion polymerization.The physico-chemical properties and film-forming potential of the dispersions were investigated while the mechanical properties of the formed film and the drug release behavior when atenolol pellets were coated with the aqueous polymer dispersions were evaluated.Results:The prepared aqueou...

关 键 词：聚合物水分散体 高延展性 缓释包衣 制备 

分 类 号：R94[医药卫生—药剂学]