虫草菌酸性胞外多糖的抗氧化作用  

Antioxidant activity of an exopolysaccharide from cultivated Cordyceps sisnensis fungus

作　　者：盛璐[1] 李静[1] 陈佳萍[1] 张伟云[1] 

机构地区：[1]南京大学医学院江苏省医学分子技术重点实验室,南京210093

出　　处：《中国药科大学学报》2009年第4期370-373,共4页Journal of China Pharmaceutical University

基　　金：国家自然科学基金资助项目(No.30873188)~~

摘　　要：目的:研究虫草菌酸性胞外多糖(EPS-A)的抗氧化作用。方法:体外建立大鼠嗜铬细胞瘤PC12细胞氧化损伤模型,测定EPS-A对细胞内丙二醛(MDA)含量和超氧化物歧化酶(SOD)活力的影响;采用小鼠移植性肝癌模型,测定不同剂量EPS-A对荷瘤小鼠肝、脑和血清中MDA水平及SOD活力的影响。结果:EPS-A显著提高体外培养细胞的抗H2O2氧化能力;能逆转因移植肿瘤而引起的小鼠组织中MDA的升高和SOD的降低,同时显著抑制肿瘤生长。结论:EPS-A具有显著的抗氧化能力。Aim:To preliminarily investigate the antioxidant activity of the acidic exopolysaccharide(EPS-A) from cultivated Cordyceps sisnensis in vitro and in vivo.Methods:PC12 cells were injured by H2O2 after the cells were treated with different doses of EPS-A for 6 h,and then the levels of malondialdelyde(MDA) and superoxide dismutase(SOD) in PC12 cells were determined.H22 cells were inoculated into the right oxter of each mouse after ICR mice were treated with EPS-A for 7 days,and tumor-bearing mice were treated ...

关 键 词：虫草 酸性胞外多糖 抗氧化 超氧化物歧化酶 丙二醛 

分 类 号：R285.5[医药卫生—中药学]