四君子汤加柴胡对长期摄酒小鼠血脂及抗氧化作用的影响  

Effect of Sijun decoction with bupleurum falcatum on blood lipid and its anti-oxidation ability in alcohol-intake mice

作　　者：张菊娥[1] 陈小让[2] 张翠英[3] 张贵星[1] 

机构地区：[1]郑州大学基础医学院生物化学与分子生物学教研室,郑州450001 [2]郑州大学药学院,郑州450001 [3]郑州大学第五附属医院内科,郑州450052

出　　处：《郑州大学学报（医学版）》2009年第5期1045-1047,共3页Journal of Zhengzhou University(Medical Sciences)

摘　　要：目的:探讨四君子汤加柴胡对长期摄酒小鼠血脂和抗氧化能力的影响。方法:ICR小鼠30只,随机分为正常组、乙醇组和四君子汤加柴胡组,每组10只,各组每d分别给生理盐水、乙醇和四君子汤加柴胡加乙醇灌胃;5周后取血用分光光度法测定血清超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、过氧化氢酶(CAT)、脂质过氧化物(LPO)和血脂含量。结果:3组间血清SOD、CAT、GSH-Px、LPO和TC、TG、HDL-C、LDL-C含量比较,差异均有统计学意义(F分别为:91.50,31.56,8.75,14.95,37.08,39.43,3.62,32.60,P均<0.05);与正常组和四君子汤加柴胡组相比,乙醇组小鼠血清中LPO、TC、TG和LDL-C含量显著增加;SOD、GSH-Px和CAT活性明显降低;四君子汤加柴胡组的SOD、CAT和GSH-Px活性及LPO含量水平与正常组比较差异无统计学意义。结论:四君子汤加柴胡能提高小鼠血清SOD、CAT和GSH-Px的活力,降低LPO及血脂含量,起到抗氧化、解毒和抗衰老作用。Aim:To explore the effect of Sijun decoction with bupleurum falcatum on blood lipid and its anti-oxidation ability in alcohol-intake mice.Methods:Thirty ICR mice were divided randomly into 3 groups,and were given normal saline,alcohol,and alcohol plus Sijun decoction with bupleurum falcatum.After five weeks,the level of the glutathione peroxidase(GSH-Px),catalase(CAT),superoxide dismutase (SOD) activity,lipid peroxides (LPO) in the serum and blood lipid were assayed by spectrophotometry.Results:There were s...

关 键 词：四君子汤 柴胡 乙醇 超氧化物歧化酶 谷胱甘肽过氧化物酶 过氧化氢酶 脂质过氧化物 小鼠 

分 类 号：R285.5[医药卫生—中药学]