辛伐他汀对COPD患者细胞凋亡和炎症因子的干预作用  

Effects of Simvastatin on the levels of plasma Fas/Apo-1 and inflammatory factors in patients with chronic obstructive pulmonary disease

作　　者：王永彬[1] 王伟[1] 

机构地区：[1]山东大学第二医院呼吸内科,济南250033

出　　处：《山东大学学报（医学版）》2009年第8期75-78,共4页Journal of Shandong University:Health Sciences

摘　　要：目的探讨辛伐他汀对慢性阻塞性肺疾病(COPD)稳定期患者的抗炎及调节细胞凋亡的作用及其机制。方法随机将60例COPD稳定期患者分为干预组和对照组,干预组给予辛伐他汀20 mg顿服,治疗8周,于治疗前、后记录临床症状得分并检查肺功能、血浆Fas/Apo-1、肿瘤坏死因子-α(TNF-α)及白介素-8(IL-8)的含量。健康对照组27例,不予处理,只采血检测。结果COPD稳定期患者血浆Fas/Apo-1、TNF-αI、L-8水平均明显高于健康对照组(P<0.05);治疗后干预组和对照组的FEV1和FEV1占预计值(%)较本组治疗前无明显差异(P>0.05),临床症状得分、Fas/Apo-1、TNF-αI、L-8水平两组相比明显降低(P<0.05);干预组的临床症状得分、Fas/Apo-1、TNF-αI、L-8水平均较本组治疗前明显降低(P<0.05),而COPD对照组治疗前、后差异不显著。结论辛伐他汀对COPD稳定期患者有抗炎和调节细胞凋亡作用。Objective To observe the influence of simvastatin on clinical symptoms,pulmonary function and plasma levels of Fas/Apo-1,tumor necrosis factor-α(TNF-α)and interleukin-8(IL-8) in patients with chronic obstructive pulmonary disease(COPD) and investigate the therapeutic action of Simvastatin on COPD.Methods Sixty COPD patients during a stable phase were randomly divided into two groups on average and received either simvastatin 20 mg once daily(the intervention group) or a placebo(the control group) for 8 week...

关 键 词：肺疾病 慢性阻塞性 细胞凋亡 炎症 辛伐他汀 

分 类 号：R563.9[医药卫生—呼吸系统]