三维能量多普勒超声检测宫颈癌的血流与MVD、VEGF表达的相关性研究  

Correlation between Three-dimensional Color Power Angiography,MVD and VEGF Expression in Cervical Carcinoma

作　　者：李平[1] 王学梅[1] 张雨芹[1] 刘艳君[1] 陶春梅[1] 

机构地区：[1]中国医科大学附属第一医院超声诊断科,沈阳110001

出　　处：《中国医科大学学报》2009年第11期846-848,共3页Journal of China Medical University

基　　金：辽宁省自然科学基金资助项目(20082098)

摘　　要：目的探讨经阴道三维能量成像(3D-CPA)检测宫颈癌的血流与微血管密度(MVD)及血管内皮生长因子(VEGF)表达的关系。方法对30例慢性宫颈炎(对照组)、34例宫颈上皮内瘤变(CIN)及44例宫颈癌患者进行经阴道3D-CPA检测,判断血管分级并计算血管指数(VI)。术后病理标本进行免疫组化染色,检测MVD及VEGF表达水平,血管分级及VI与免疫组化结果进行相关性分析。结果从慢性宫颈炎、CIN到宫颈癌,MVD及VEGF的阳性表达率升高,与对照组比较差异有统计学意义(P<0.05)。Ⅲ级血管的MVD、VEGF表达阳性率高于I、Ⅱ级(P<0.01);VI与MVD、VEGF表达有相关性(分别为r=0.782,P<0.01;rs=0.86,P<0.01)。结论血管分级、VI与MVD、VEGF的表达具有相关性,3D-CPA检测的血流能够反映宫颈癌的新生血管情况。Objective To study the correlation between vascular index(VI),vascular pattern,microvessels density(MVD)and the expression of vascular endothelial growth factor(VEGF).Methods Totally 30 patients with chronic cervicitis,34 with cervical intraepithelial neoplasia(CIN)and 44 with cervical carcinoma were examined preoperatively with three-dimensional color power angiography(3D-CPA).The vascular pattern and VI of the cervix were determined.Immunochemistry(S-P technique)with CD34 and VEGF antibody were employed t...

关 键 词：三维超声 能量多普勒 宫颈癌 微血管密度 血管内皮生长因子 

分 类 号：R445.1[医药卫生—影像医学与核医学]