TTV在非甲～庚型肝炎患者中的检测及序列分析  

Detection of TTV infection and sequence analysis in patients with nonA - G hepatitis

作　　者：周小平[1] 邓明德[1] 李爱月[1] 李向霞[1] 李瑾革[2] 

机构地区：[1]兰州市解放军第一医院传染科,730030 [2]西安市第四军医大学唐都医院感染科,710038

出　　处：《实用肝脏病杂志》2003年第2期83-84,共2页Journal of Practical Hepatology

摘　　要：目的研究TTV在非甲-庚型肝炎患者中的感染状况及临床意义。方法 采用套式PCR法检测50例非甲-庚型肝炎患者血清标本中TTV DNA,并对其中一株TTV的部分基因序列进行了测定。结果 在50例肝炎患者中,TTV DNA阳性检出率为28.0％(14/50)。TTV序列分析与日本株的同源性为98％。结论TTV感染可能是非甲-庚型肝炎的病因之一。50 serum samples from patients with nonA - G hepatitis were detected for TTV DNA by nested - PCR method. Partial gene of a TTV isolate was directly sequenced.The results showed that 14 of 50(28% )were positive for TTV DNA.The results suggest that TTV is associated with acute,chronic and fulminant hepatitis,and TTV infection would be the important cause of nonA- C hepatitis.

关 键 词：输血传播病毒 聚合酶链反应 非甲~庚型肝炎 

分 类 号：R512.6[医药卫生—内科学]