牵张刺激诱导心肌细胞NF-κB的激活与转位  

Activation and translocation of NF-κB induced by stretching cardiac myocytes

作　　者：刘荣韬[1] 尹华虎[1] 王正荣[1] 

机构地区：[1]华西医科大学基础医学院生物医学工程研究室,成都610041

出　　处：《四川生理科学杂志》2001年第1期12-15,共4页Sichuan Journal of Physiological Sciences

摘　　要：应用免疫组化方法观察牵张刺激对心肌细胞中NF-κB分布的影响,探讨牵张刺激对心肌细胞NF-κB的激活作用。结果显示,未受牵张与牵张1小时的心肌细胞中,NF-κB位于胞浆,牵张3小时的心肌细胞中NF-κB位于胞浆及核膜周围,牵张5小时的心肌细胞中,NF-κB位于胞核。表明心肌细胞受到一定的牵张刺激后,NF-κB可以被激活而由胞浆转位到胞核。Immunohistochemical method was applied to observe the activition of NF-κB in stretched cardiac myocytes. It was found that NF-κB spread all over the cytosol in the cardiac myocytes non-stretched and stretched for 1 hour. After stretching cardiac myocytes 3 hours, NF-κB moved to nucleic memberane. After stretching cardiac myocytes 5 hours, NF-κB translocated into nuclei. The results showed that the stimultion of stretch can induced activation of NF-κB.

关 键 词：牵张 NF-ΚB 转位 心肌细胞 

分 类 号：R318.01[医药卫生—生物医学工程]