种属差异对实验性高脂血症的影响  

Effects of race difference on experimental hyperlipidemia models in animals

作　　者：杨俊卿[1] 周岐新[1] 李远宗[1] 

机构地区：[1]重庆医科大学药理教研室,重庆400016

出　　处：《四川生理科学杂志》2001年第4期171-173,共3页Sichuan Journal of Physiological Sciences

摘　　要：目的:观察动物种属差异对实验性高脂血症的影响。方法:分别用老年小鼠、正常大鼠和正常家兔建立动物高脂血症模型,以动物血清胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)和高密度脂蛋白(HDL)为指标。研究不同动物种属建立的高脂模型中,上述指标变化是否存在差异。结果:实验发现老年小鼠血清LDL和TC升高,HDL变化不明显,而TG则下降;大鼠血清TC和LDL显著升高,HDL明显下降,而TG未见显著升高;家兔血清TG、TC和LDL显著升高,而HDL也明显升高。结论:动物种属差异对实验性高脂血症存在显著影响。To evaluation effects of race difference on experimental hyperlipidemia models in mice, rats and rabbits. Methods: Hyperlipidemia models of aging mice, rats and rabbits fed on a diet of cholesterol, fat and etc were established. TC、TG、DL and HDL in serum of animals were measured. Results: The hyperlipid diet significantly increased serum TC and LDL in all models; serum TG and HDL also increased in rabbits; serum HDL obviously decreased and TG had a little change in rats, with contrast to that in aging mice. Conclusion: Race difference has significantly effects on experimental hyperlipidemia models in animals.

关 键 词：血脂 模型 动物种属 

分 类 号：R589.2[医药卫生—内分泌]