静脉注射红霉素增强狗的胃肠移行性复合运动  

Intravenous infusion of erythromycin enhances the interdigestive migrating motor complex in dogs

作　　者：杨春敏[1] 毛高平[1] 张秀荣[1] 张映辉[1] 步晓华[1] 曹传平[1] 

机构地区：[1]空军总医院消化科,北京100036

出　　处：《空军总医院学报》2001年第1期1-4,共4页Journal of General Hospital of Air Force,PLA

摘　　要：目的　观察静脉注射红霉素对狗消化间期胃肠移行性复合运动 (MMC)的作用。　方法　应用低顺应性毛细管水灌注消化道腔内测压系统记录清醒狗胃肠收缩活动。在 MMC 相静脉注射红霉素记录胃肠运动变化并抽血测定血浆胃动素浓度。　结果　 (1)血浆胃动素随 MMC不同时相呈周期性波动 ,血浆胃动素浓度在 MMC 相时最高 ,MMC 相时最低。(2 )在 MMC 相时从静脉注射红霉素可以激发胃和十二指肠 MMC 相收缩 ,但不伴有血浆胃动素升高。引起狗 MMC 相收缩的最适红霉素浓度为 0 .5 mg· kg- 1 ;红霉素 10 m g· kg- 1引起胃肠持续收缩并出现十二指肠 -胃逆蠕动 ,导致恶心呕吐。(3)阿托品明显抑制红霉素所致的胃和十二指肠 MMC 相收缩。　结论　红霉素有促进胃肠动力作用 ,红霉素引起胃肠收缩作用的机制与胃动素释放无关 。Aims To observe the effect of intravenous injection of erythromycin (EM) on interdigestive migrating motor complex (MMC) and postprandial gastrointestinal contraction in conscious dogs. Methods Gastrointestinal contractile activity was recorded using low compliance capillary water perfusion manometric system. EM was administered intravenously during phaseⅠand after meal, and blood samples were drawn for measuring plasma motilin concentrations. Results (1) Plasma motilin levels showed cyclical fluctuations in different phases of MMC, and plasma motilin reached peak during phaseⅢ and lowest during phaseⅠ.(2) EM induced phaseⅢ like contractions in the antrum and duodenum, which was not accompanied by a peak in plasma motilin level. The optimum dose of EM for resulting in a premature phaseⅢ with the same characteristics as the spontaneously occurring phaseⅢ was established to be 0.5 mg·kg -1 . The dose of 10 mg·kg -1 EM induced gastrointestinal continuous contractions and duodeno-gastric retrograde peristalsis which was associated with retching and vomiting. (3) Atropine obviously inhibited EM induced phaseⅢ activity in the antrum and duodenum. Conclusions EM is a potent prokinetic agent, which is promising for treatment of gastrointestinal dysfunction diseases. The mechanism by which EM induced gastrointestinal contractions is not related to the release of motilin, but may be mediated partially by cholinergic pathway.

关 键 词：胃肠运动 红霉素 促胃动素 

分 类 号：R333[医药卫生—人体生理学] R978.15[医药卫生—基础医学] R977.1