骨密度和白介素-1β及白介素-6在Graves病时的改变及其相关关系  

Changes and correlation of bone mineral density and interleukin-1β and interleukin-6 in patients with Graves Disease

作　　者：宋志民[1] 逄曙光[1] 马冬英[1] 张承薇[1] 孙金凤[1] 

机构地区：[1]济南市中心医院,250000

出　　处：《中国骨肿瘤骨病》2002年第4期233-235,共3页Chinse Journal Of Bone Tumor And Bone Disease

摘　　要：目的研究Graves病(简称GD)时骨密度(BMD)和白介素-1β(IL-1β)及白介素-6(IL-6)的变化,探讨Graves病时骨密度与IL-1β及IL-6改变的相关关系。方法对106例GD病人和50名健康人应用双能双光子骨密度仪测定了其桡骨远端骨密度,用ELISA法测其IL-1β和IL-6水平,并在各组之间进行比较。结果GD病人骨密度水平显著低于正常对照组,IL-1β和IL-6水平在GD未治疗组显著高于缓解组和正常对照组,骨密度与IL-1β和IL-6水平呈显著负相关关系。结论Graves病病人骨密度的降低与IL-1β和IL-6的升高有关。Objective To investigate the changes of bone mineral density(BMD) ,interleukin - 1β(IL-1β), interleukin - 6(IL-6) and explore the correlations among them in patients suffering from Graves s disease(GD) . Methods BMD were measured by aual - energy x - ray absorptiometry, IL - 1βAND IL - 6 were determined from sera by enzyme - linked immunosor-bent assay(ELISA)in all subjects. Result BMD were reduced significantly in GD group compared with normal control. Serum IL- lβand IL- 6 values were significantly increased in untreated GD group compared with normal control and remission group. There was a negative correlation between BMD and IL - 1β, IL - 6. Conclusion The decrease of BMD in patients with Graves Disease seems to be correlated with the increase of IL - 1β and IL - 6.

关 键 词：格雷夫斯病 骨密度 白细胞介素1 白细胞介素6 

分 类 号：R581.1[医药卫生—内分泌]