三七总皂甙和灯盏花素复方注射剂对结扎大鼠冠脉致心肌缺血的保护作用  

PROTECTIVE EFFECTS OF COMPLEX INJECTION MADE FROM TOTAL SAPONINS OF PANAX NOTOGINSENG AND ERIGREON BREVISCAPUS IN MYOCARDIAL ISCHEMIA RAT BY LIGATURING LEFT CORONARY ARTERY

作　　者：雷秀玲[1] 董雪峰 杨雁华[1] 李玲[3] 陈植和[3] 

机构地区：[1]昆明医学院基础药理教研室,昆明650031 [2]昆明滇虹药业有限公司,昆明650101 [3]云南省天然药物药理重点实验室

出　　处：《天然产物研究与开发》2002年第3期54-57,共4页Natural Product Research and Development

基　　金：云南省自然科学青年基金资助项目No :96C0 76Q

摘　　要：采用结扎大鼠冠脉造成急性心肌缺血模型 ,观察了三七总皂甙和灯盏花素复方注射剂 (简称复方注射剂 )抗实验性心肌缺血作用。结果表明 :大鼠静脉注射复方注射剂 5 0mg/kg和 10 0mg/kg对急性心肌缺血均有一定程度的保护作用 ,在改善心电图S T段的上移、降低血清CPK、LDH方面两个剂量组均有显著作用 (P <0 .0 5 ,P <0 .0 1)以 10 0mg/kg组缩小心肌梗塞范围为显著 (P <0 .0 5 )。复方注射剂与丹参注射剂均能保护超氧化物歧化酶活性 (P <0 .0 5 ,P <0 .0 1) ,显著降低丙二醛含量 (P <0 .0 1)。复方注射剂两个剂量组均能显著增加前列环素合成 (P <0 .0 5 ,P <0 .0 1)。提示三七总皂甙和灯盏花素复方注射剂对心肌缺血的保护作用与抗脂质过氧化作用有关 ,其促进前列环素合成作用可能与其抗心肌缺血有关。Complex injection made from total saponins of Panax Notoginseng and Erigreon breviscapus which protects against ischemia injury from myocardial reperfusion injury.It is considered as the treatment of coronary heart disease in folk.In this paper,an acute myocardial ischemia model by ligaturing left descending coronary artery on rat was made,which increased S T sigments in ECG.The complex injections after introvein injection can protect against S T sigment significant raise.The complex injections at 50 mg/kg or 100 mg/kg significantly inhibited S T sigments increases,narrowed myocardial infract size( P <0.05),decreased cardiac CPK and LDH release( P <0.05, P <0.01),prevented reduction of superoxide dismutase(SOD)activity( P <0.05, P <0.01),reduced malondialdehyde(MDA)production( P <0.01).The complex injection also increased levels of PGI 2 in serum( P <0.05) after experimental acute myocardial ischemia.The results show that the complex injection prevents cardiac ischemia and the action is considered to be related to the inhibition of lipid peroxidation.

关 键 词：由三七总皂甙和灯盏花素组成的复方注射剂 心肌缺血 LDH CPK SOD MDA PGI2 TXA2 

分 类 号：R93[医药卫生—生药学]