瓜叶乌头中生物碱成分的研究  

STUDIES ON C_19 -DITERPENOID ALKALOIDS OF ACONITUM HEMSLEYANUM PRITZ

作　　者：周先礼[1] 简锡贤[2] 王锋鹏[2] 

机构地区：[1]西南交通大学生物工程系,成都610031 [2]四川大学华西药学院天然药物化学教研室,成都610041

出　　处：《天然产物研究与开发》2002年第5期14-17,共4页Natural Product Research and Development

摘　　要：从瓜叶乌头 (AconitumhemsleyanumPritz)根中分得 12个已知C19 二萜生物碱 ;氨茴酰牛扁碱(anthranoyllycoctonine) 1、牛扁碱 (lycoctonine) 2、8 去乙酰滇乌碱 (8 deacetylyunaconitine) 3、伪乌头宁(pseudaconine) 4、sachaconitine 5、尼奥宁 (neoline) 6、senbusineA 7、6 表弗斯生 (6 epiforesticine) 8、滇乌碱(yunaconitine) 9、印乌碱 (indaconitine) 10、查斯曼宁 (chasmanine) 11、和塔拉萨敏 (talatisamine) 12。其中化合物 1～ 8是首次从该植物中分离得到。应用光谱法和对照TLC鉴定了所有化合物的结构。From the roots of Aconitum hemsleyanum Pritz,twelve known C 19 diterpenoid alkaloids:anthranoyllycoctonine 1,lycoctonine 2? 8 deacetylyunaconitine 3, pseudaconine 4, sachaconitine 5, neoline 6, senbusine A 7,6 epiforesticine 8,yunaconitine 9,indaconitine 10,chasmanine11 and talatisamine 12 were isolated.Compounds 1～8 were isolated from this plant for the first time.Their structures were identified on the basis of spectral data and TLC comparison.

关 键 词：瓜叶乌头 C19-二萜生物碱 

分 类 号：R28[医药卫生—中药学]