中药清热凉血新法治疗温病湿热证的实验研究  

Experimental Study of Treatment of Damp-heat Syndrome of Seasonal Febrile Disease With Traditional Chinese Medicine to Clear Away Heat and Cool blood

作　　者：张艺平[1] 韩鹏[1] 刘诚[1] 马国亮[1] 李贞[1] 刘仕昌[2] 彭胜权[2] 

机构地区：[1]解放军157医院,广州510510 [2]广州中医药大学温病教研室

出　　处：《华南国防医学杂志》2002年第6期1-5,共5页Military Medical Journal of South China

摘　　要：目的:探讨清热解毒、凉血化瘀对南方战区常见病证温病湿热证的作用,并从微观角度探讨温病湿热证血瘀的客观性。方法:采用复合因素复制的新西兰兔温病湿热证模型,设立黄连解毒汤组(A组),黄连解毒汤加丹参、赤芍组(B组),王氏连朴饮组(C 组),王氏连朴饮加丹参、赤芍组(D 组),湿热证模型组(E 组),正常对照组(F 组)。观察各组症状及体温变化、血浆内毒素(ET)、肿瘤坏死因子(TNF)、白细胞介素-1(IL-1)、血液流变学、血小板、凝血功能、血栓素B_2(TXB_2)、6-酮-前列腺素F_(1a)(6-keto-PGF_(1a))等指标变化。结果:黄连解毒汤加丹参、赤芍组症状表现较轻,黄连解毒汤组及黄连解毒汤加丹参、赤芍组体温升高较小,药物治疗各组ET、TNF、IL-1较模型对照组显著降低(P<0.05～0.01),黄连解毒汤组,黄连解毒汤加丹参、赤芍组ET、IL-1的含量尚低于王氏连朴饮组,有显著性差异(P<0.05)。湿热模型组血液流变学各参数、血小板数及聚集率、凝血指标、TXB_2、6-keto-PGF(1a)与正常对照组比较有非常显著性差异(P<0.01)。黄连解毒汤加丹参、赤芍组,王氏连朴饮加丹参、赤芍组在改善上述指标效果较好,优于黄连解毒汤组、王氏连朴饮组,有显著性差异(P<0.05～0.01)。结论:清热解毒、凉血化瘀对于南方战区常见温病湿热证具有较好的治疗作?Objectives To explore the effects of traditional Chinese medicine for clearing away heat and removing toxic substances (CHRTS,清热解毒) , and cooling blood to dissipate blood stais(CBDBS,凉血化瘀)on damp-heat syndrome of seasonal febrile disease (DHSSFD,温病湿热症),which is clinically common in our south war zone ,and to study objectivity of blood stasis of DHSSFD from microcosmic angle. Methods DHSSFD models were established in the rabbits by compound factors and randomly divided into Huanglian Jiedu decoction group(黄连解毒汤组,group A), Huanglian Jiedu decoction plus Salvia miltiorrhiza(SM,丹参)and Paeonia lactiflora (PL,赤芍)group (黄连解毒汤加丹参、赤芍组, group B), Wang's Lianpu drink group (王氏连朴饮组, group C), Wang'sLian-pu drink plus SM and PL group(王氏连朴饮加丹参、赫芍组, group D), control group (group E) and normal group(group F). The changes in symptom and temperature, plasma levels of endotoxin(ET), tumor necrosis factor(TNF) ,interleukin-l(IL-1), thromboxin B2(TXB2),6-keto-prostaglandin F1α(6-keto-PGFt1α),platelet, thrombin parameters and blood rheology (BR) parameters were observed. Results The symptom in group B was slighter than that in the control group. There was a relatively small increase in temperature in group A and group B. The contents of ET, TNF and IL-1 in plasma in every treatment group were significantly lower than that in the control group( P<0.05 or 0.01). The contents of ET, IL-I in plasma in group A and group B were significantly lower than that in group C ( P<0.05). BR parameters, platelet and its aggregation rate, thrombin parameters, TXB2 and 6-keto-PGF1α in the control group were significantly different from those in normal group(P<0.01). The curative effect on improving the above mentioned parameters was better in groups B and D than that in groups A and C ( P<0.01). Conclusions The curative effect of CHRTS on clinically common DHSSFD in our south war zone is good.

关 键 词：湿热证 清热解毒 凉血化瘀 黄连解毒汤 王氏连朴饮 丹参 赤芍 

分 类 号：R254[医药卫生—中医内科学]