Bcl-2和Bax在子宫内膜异位症的表达及意义  

Expression of Bcl-2 and Bax and their significance in endometriosis

作　　者：王化丽[1] 王莲芬[1] 汪洁平[1] 曹锐[1] 

机构地区：[1]大连市妇产医院,116033

出　　处：《中国妇产科临床杂志》2003年第5期378-381,共4页Chinese Journal of Clinical Obstetrics and Gynecology

摘　　要：目的　研究正常人子宫内膜和子宫内膜异位症 (内异症 )的在位内膜和异位内膜Bcl- 2、 Bax的表达和细胞凋亡率 ,探讨细胞凋亡在月经周期变化和内异症发生中的作用。方法　应用免疫组织化学方法和流式细胞学检测技术 ,检测 6 0例正常人子宫内膜和 4 7例内异症患者子宫内膜Bcl - 2、Bax的表达及细胞凋亡率。结果　①正常子宫内膜Bcl- 2在增生期表达进行性增强 ,在分泌期无表达。Bax在增生期弱表达 ,在分泌期表达增强 ;②Bcl- 2在内异症的在位内膜、异位内膜的表达增生期强于分泌期 ,异位内膜强于在位内膜。Bax在内异症的在位内膜、异位内膜的表达增生期弱于分泌期 ,异位内膜弱于在位内膜 ;③分泌期正常子宫内膜的凋亡率高于内异症的在位内膜和异位内膜。结论　Bcl- 2、Bax参与调控正常子宫内膜形态与功能变化 ,其异常表达导致子宫内膜细胞凋亡失调 ,是内膜异位症发生的分子机制之一。Objective To investigate the expression of Bcl-2 and Bax and the apoptosis percentage in normal endometrium and ectopic or eutopic endometrium with endometriosis.Methods Expression of Bcl-2 and Bax were assessed by immunohistochemical staining.Apoptosis percentage was examined by flow cytometry.Results ①Expression of Bcl-2 and Bax in normal endometrium,ectopic and eutopic endometrium of endometriosis varied cyclically.②Bcl-2 expression in endometrium of endometriosis was stronger than that in normal,and in ectopic endometrium was stronger than in eutopic.Bax expression was contrary to Bcl-2.③Apoptosis percentage of ectopic endometrium was higher than that in normal and eutopic endometrium.Conclusions Normal endometrium cyclical change is related to apoptosis.The decrease of apoptosis may play an important role in the pathogenesis of endometriosis.

关 键 词：BCL-2 BAX 细胞凋亡 子宫内膜 子宫内膜异位症 

分 类 号：R711.71[医药卫生—妇产科学]