原子吸收光谱法测定高血压合并高血脂症患者血清铜和锌  

Determination of Trace Copper and Zinc in Hypertension Complicated with Hyperlipemia by Atomic Absorption Spectrophotometry

作　　者：何邦平[1] 李东方[2] 马建伟 陈杰[1] 刘小宇[1] 张欣荣[1] 徐建明[1] 

机构地区：[1]第二军医大学药学院,上海200433 [2]第二军医大学基础医学部,上海200433 [3]上海市浦东新区东方医院,上海200120

出　　处：《光谱学与光谱分析》2004年第6期741-743,共3页Spectroscopy and Spectral Analysis

基　　金：国家自然科学基金 (39370 61 2 );上海市科技发展基金(91 4 1 1 30 60 )资助项目

摘　　要：采用原子吸收光谱法和试剂盒分别检测了 4 4例高血压合并高血脂症患者、4 2例单纯高血压病患者的血清Cu ,Zn及胆固醇 (Ch)、甘油三脂 (TG) ,并与 30例正常对照组进行比较分析。结果发现高血压合并高血脂症患者的血清Zn ,Zn/Cu比值及Ch ,TG均明显高于单纯高血压组和对照组 ,血清Cu则低于单纯高血压组及对照组 (P <0 0 1) ;单纯高血压组血清Zn ,Zn/Cu及Ch和TG有增高的趋向。研究结果提示血清中Cu和Zn含量变化与高血压合并高血脂症有密切的关系。The serum levels of Zn, Cu, cholesterol (Ch) and triglyceride (TG) were determined in 44 patients with hypertension complicated with hyperlipemia, 42 patients with hypertension( HP) and 30 healthy controls by atomic absorption spectrophotometry and automatic biochemical analytical instrument of reagent kit. It was found that the contents of Zn, Ch, TG and Zn/Cu ratio in hypertension complicated with hyperlipemia were significantly higher than in HP and control, while Cu in hypertension complicated with hyperlipemia was significantly lower than in HP and control. The contents of Zn, Ch, TG and Zn/Cu ratio in hypertension were significantly increased. It is suggested that hypertension complicated with hyperlipemia is closely related with Zn and Cu.

关 键 词：高血压合并高血脂症 血清 铜 锌 含量测定 原子吸收光谱法 

分 类 号：R589.2[医药卫生—内分泌] R544.1[医药卫生—内科学]