拟南芥植物中的双组分信号系统  

Two component system in arabiodopsis plants

作　　者：刘亚娟[1] 于荣[1] 黄丛林[2] 吴忠义[2] 

机构地区：[1]首都师范大学生物系,北京100037 [2]北京农业生物技术研究中心,北京100089

出　　处：《生物信息学》2004年第2期21-26,共6页Chinese Journal of Bioinformatics

基　　金：北京市科委项目(H012010240113;H020821330130);留学回国人员启动资金项目。

摘　　要：双组分信号系统是普遍存在于原核和真核细胞中,在进化上较保守的信号转导系统,主要由组氨酸蛋白激酶和应答调控器组成。双组分信号系统在植物的生长和发育中起非常重要的作用。随着拟南芥基因组测序的完成和功能基因组的深入研究发现,在拟南芥基因组中有55种参与双组分信号系统磷酸传递的蛋白。本文应用生物信息学的基本手段,如序列比较、多个序列比对、系统进化树分析、跨膜区分析、二级结构预测等,对这些蛋白进行系统分类,结构分析,并对在信号转导中已知功能的蛋白进行归类总结,便于人们了解双组分信号系统的作用机制及其在植物中的功能。Two - component systems are involved in various signal transduction pathways in both prokaryotes and eukaryotes. Two - component system that relies upon phosphorylation of histidine and aspartic - acid residues, typically works as a receptor with histidine - kinase activity and a response regulator. Evidence now shows that it plays essential roles in the growth and development of plants. After the accomplishment of sequence analysis of the entire Arabidopsis genome and with the further research on functional genome, it has been revealed that there are at least 55 genes encoding proteins with homology to all elements of the'two - component system'. In this article, we use basic methods of bioin-formatics, such as blast clustalw, phylogenetic tree, HMM, prediction of secondary structure etc, to draw a systematic classification of two - component signaling elements,as well as a summary of the function they conduct in the signal transduction.

关 键 词：双组分系统 组氨酸蛋白激酶 应答调控器 

分 类 号：Q943.2[生物学—植物学]