互作蛋白质与复合物亚基的基因表达相关性比较分析  

Comparative analysis of gene expression correlation between interactive proteins and among subunits of protein complexes

作　　者：王磊[1] 郭政[1] 李霞[1] 屠康[1] 喻辉[1] 李雪森 王辰光[1] 

机构地区：[1]哈尔滨医科大学生物信息学研究室,哈尔滨150086

出　　处：《生物信息学》2004年第4期1-4,29,共5页Chinese Journal of Bioinformatics

基　　金：国家自然科学基金 (3 9970 3 97;3 0 170 5 15 ;3 0 3 70 3 88) ;国家 863计划 (2 0 0 2AA2Z2 0 5 2 ;2 0 0 3AA2Z2 0 5 1) ;黑龙江科技攻关重点 (GB0 3C60 2 -4 ) ;黑龙江自然科学基金 (F0 177) ;哈尔滨市科技攻关 (2 0 0 3AA3CS113 );哈尔滨医科大学 2 11工

摘　　要：利用在多种应激条件下酵母的基因表达谱数据 ,分别计算互作蛋白质及复合物亚基编码基因的表达相关性。结果发现 ,相对于随机对照组 ,互作蛋白质的编码基因与蛋白质复合物的编码基因表达相关性均显著 (P <0 .0 1) ,即互作蛋白质及复合物亚基有共表达的倾向。通过比较 ,进一步发现蛋白质复合物亚基的基因表达相关性显著高于互作蛋白质的基因表达相关性 (P <0 .0 1) ,这与复合物亚基之间功能联系强于定义不甚确切的互作蛋白之间功能联系现象吻合。Gene expression correlations of interacting proteins and subunits of protein complexes are investigated respectively,using various yeast gene expression profiles under different stresses.Both genes that coding interactive proteins and protein complex subunits demonstrate significant mRNA expression correlation(P<0.01),suggesting a trend of coexpression between interactive proteins and among protein complex subunits compared with randomly control groups.Furthermore,it reveals that genes coding subunits of the same protein complex are more likely to coexpress than genes coding interactive proteins (P<0.01),possibly due to the fact that the functional coherence among protein complex subunits are much higher than that of interactive proteins whose functional relationship is not clearly defined.

关 键 词：蛋白质互作 蛋白质复合物 基因表达相关性 

分 类 号：Q786[生物学—分子生物学]