用正交实验优选人工肾透析液中钙、镁含量测定方法  

Optimizing the assay method of calcium and magnesium in the dialysis solution for artificial kidney by orthogonal experiment

作　　者：万红卫[1] 钱佳星 金仁达 

机构地区：[1]江苏省常熟市新区医院药剂科,常熟215500

出　　处：《中国药物应用与监测》2005年第6期16-19,共4页Chinese Journal of Drug Application and Monitoring

摘　　要：目的:用正交设计优选人工肾透析液钙镁含量测定条件。方法:用L9(34)正交设计表对温度、掩蔽干扰离子的掩蔽剂进行多因素、多水平试验。结果:滴定的温度20℃、在被测溶液中加入适量的水、乙醇和三乙醇胺能使滴定终点突跃明显,终点易于判断。结论:采用优选条件后,能显著提高钙镁测定的精确度、准确度,重现性好。Objective:To optimize the assay method of calcium and magnesium in the dialysis solution for artificial kidney.Methods:Orthogonal design was applied to multiple factor and multilevel experiment about temperature and the agent of the screening interfering ion.Results:Adding water,alcohol and triethanolamine and when the temperature is at 20℃ make the titration end-point keen and easy to decision.Conclusion:The optimized method visibly increase the precision and accuracy of the determination of calcium and magnesium,and the reproducibility of the assay is well.

关 键 词：人工肾透析液 正交设计 钙镁含量测定 

分 类 号：R927[医药卫生—药学]