2004新药与同类药物(4种)动物耳毒性实验观察  

Aminoglycoside antibiotics 2004 ototoxicity comparative with gentamicin,netilmicin,etilmicin and verdamicin

作　　者：胡吟燕[1] 孙建和[1] 于宁[1] 郭维[1] 赵承军[1] 夏辉[1] 

机构地区：[1]解放军总医院耳鼻咽喉科,北京100853

出　　处：《中国药物应用与监测》2005年第6期40-44,共5页Chinese Journal of Drug Application and Monitoring

摘　　要：目的:观察氨基糖苷类新药2004与同类药物(4种)对动物的耳毒性。方法:120只白化豚鼠分别肌注同剂量的抗生素新药2004、庆大霉素、奈替米星、依替米星、威大霉素及生理盐水,21d后通过观察听性脑干反应阈值,通过眼震电图观察眼震抑制率(F),了解其听功能及前庭功能的变化;结合耳蜗铺片琥珀酸脱氢酶染色、火棉胶切片等方法观察耳蜗及前庭器官的形态学变化。结果:ABR阈移、耳蜗铺片毛细胞计数及内、外毛细胞的损害情况和病变范围、火棉胶切片观察结果同时表明这些药物的耳蜗毒性:庆大霉素>威大霉素>奈替米星>依替米星>新药2004。眼震抑制率(F)和前庭形态学结果表明这些药物的前庭毒性:威大霉素>庆大霉素>奈替米星>依替米星>新药2004。结论:氨基糖苷类新药2004在同类药物中的耳毒性是最小的。Objective:The following aminoglycosi de antibiotics 2004,gentamicin,netilmicin,etilmicinand verdamicin were submitted to a comparative study of their ototoxicity.Methods:eletrophysiological(auditory brainstem response and electronystagmography)and morphological technique(celloidin section, surface preparations in SDH stain)were used.Results:Gentamicin-treated animals and verdamicin-treated animals demonstrated more severe evidence of ototoxicity.The mild cochlear impairment was observed in netilmicin-treated animals,No functional or structural evidence of audiotoxicity was found in animals treated with 2004.No impairment of vestibule was observed in animals treated with 2004.Conclusion:On the basis of both electro-physioogical and morphological observation,the order of auditory and vestibular toxicity was the following: gentamicin>verdamicin>netilmicin>etilmicin>2004.

关 键 词：氨基糖苷类2004 眼震电图 听性脑干反应 形态学 耳毒性 

分 类 号：R96[医药卫生—药理学]