磷酸钙骨水泥/聚乳酸-聚羟基乙酸复合材料的制备及性能  

Preparation and some property investigations on composite of calcium phosphate cements/polyglycolic-polylactic acid

作　　者：向其军[1] 刘咏[1] 郑治[2] 苏哲安[1] 王剑龙[2] 肖飞[2] 

机构地区：[1]中南大学粉末冶金国家重点实验室,长沙410083 [2]中南大学湘雅三医院,长沙410013

出　　处：《粉末冶金材料科学与工程》2005年第6期361-364,共4页Materials Science and Engineering of Powder Metallurgy

基　　金：国家自然科学基金主任基金资助项目(30370412);湖南省自然科学基金资助项目(03JJY3027)

摘　　要：为深入研究磷酸钙骨水泥(CPC)/聚乳酸-聚羟基乙酸(PLGA)生物复合材料的制备工艺及性能,也为临床应用提供理论依据,实验制备了CPC-PLGA生物复合材料;并通过测定该材料在模拟体液中浸泡后引起的浸泡液pH值的变化,以及采用JSM 5600LV型扫描电镜观察该材料在体外降解后的微观形貌,间接评估了该材料引起体液pH值的变化以及该材料降解性能对人体细胞和骨组织可能存在的影响。结果表明,所制备的CPCPLGA复合材料没有引起浸泡液pH值的较大波动,该值始终处于人体安全范围之内,对人体细胞的刺激影响将会较小;由于该材料复合了高分子聚合物PLGA,使其具有良好的降解性,可为骨组织细胞、血管等的粘附和生成创造良好的条件。To provide a theory evidence for clinical applications,and to understand the preparation and some properties of biocomposite of calcium phosphate cements(CPC)/polyglycolic-polylactic acid(PLGA),the composite of CPC-PLGA was experimentally prepared,the changes of the pH value of the CPC-PLGA composite after immersed in a simulated body fluid of human being was measured;the microstructure of CPC-PLGA after degradation was studied by Scan electron microscope JSM5600LV,therefore the potential influences on human being′s cells and bone tissues of both the pH value changes of body fluid and the degradation property of CPC-LGA composite were indirectly evaluated.Results show that pH value of the simulated body fluid changed a little,this indicates a small influence on cells;in addition,the CPC-PLGA composite exhibited a good degradation property,which could create a good place for the adherence and growth of human being cells and bone tissues.

关 键 词：磷酸钙骨水泥 聚乳酸-聚羟基乙酸 复合材料 骨修复 降解性 

分 类 号：R318.08[医药卫生—生物医学工程] R681[医药卫生—基础医学]