阴道冲洗液绒毛膜促性腺激素和甲胎蛋白检测诊断胎膜早破  

Clinical value of vaginal washing fluid β-hCG and AFP detecting in diagnosis of premature rupture of membranes

作　　者：汪学佳[1] 陈茜[1] 伍敏仪[2] 赵翠柳[1] 

机构地区：[1]广州市红十字会医院,暨南大学医学院第四附属医院妇产科,广东510220 [2]广州市红十字会医院,暨南大学医学院第四附属医院中心实验室,广东510220

出　　处：《中国生育健康杂志》2002年第4期149-151,共3页Chinese Journal of Reproductive Health

摘　　要：目的 探讨阴道冲洗液β绒毛膜促性腺激素(β-human chorionic gonadotropin,β-hCG)和甲胎蛋白(alpha fetoprotein,AFP)检测在胎膜早破诊断中的临床价值。 方法 应用微粒子化学发光分析法对42例胎膜早破和38例正常晚孕待产孕妇阴道冲洗液进行β-hCG和AFP定量测量。 结果 胎膜早破组阴道冲洗液β-hCG、AFP测量中位数值分别为294.2 IU/L和143.4μg/L,明显高于对照组的4.4 IU/L和5.0×10-2μg/L(P<0.001);四分位数间距分别为422.8 IU/L和179.2μg/L,明显高于对照组的11.0 IU/L和0.3μg/L(P<0.001);以β-hCG≥40.1 Iu/L或AFP≥16.3μg/L为阳性参考值,阳性检出率分别为97.6%(41/42)和100.0%(42/42);其诊断的敏感性分别为95.2%和97.6%;特异性分别为89.5%和100.0%。 结论阴道冲洗液β-hCG和AFP,尤其是AFP检测是胎膜早破准确及快速的诊断方法。Objective To study the clinical value of vaginal washing fluid ?-hCG and AFP detecting in diagnosis of premature rupture of membranes (PROM). Methods Vaginal washings ?-hCG and AFP were measured by qualitative analysis with chemiluminescent inimunoassay following burn injury in 42 cases with PROM (study group) and 38 cases of normal pregnant women (control group), respectively. Results The medians of ?-hCG and AFP in vaginal washing fluid of PROM were 294. 2 IU/L and 143. 4?g/L, respectively. These values were significantly higher than those (4. 4 IU/L and 5.0?

关 键 词：胎膜早破 阴道冲洗液 Β绒毛膜促性腺激素 甲胎蛋白 诊断 

分 类 号：R714.4[医药卫生—妇产科学]