男性不育患者支原体感染与精浆IL-4、IFN-γ关系探讨  

The relative study between mycoplasma infection and interleukin-4, inferon-gamma of seminal plasma in infertile males

作　　者：孙爱娣[1] 陈开森[1] 黎进[1] 廖晚珍[1] 余阳[1] 

机构地区：[1]南昌大学第一附属医院检验科,330006

出　　处：《实验与检验医学》2007年第6期536-538,共3页Experimental and Laboratory Medicine

摘　　要：目的探讨男性不育患者中支原体感染情况及精浆白细胞介素4(IL-4)、干扰素γ(IFN-γ)水平关系。方法采用支原体培养方法了解支原体感染情况,生物素双抗体ELISA夹心法测定IL-4、IFN-γ含量。结果31例男性不育症患者有20例感染支原体、感染率64.5%(20/31),其IL-4和IFN-γ含量分别为7.8±0.9pg/ml和49.1±16.4pg/ml,较男性正常生育组(3.4±1.62pg/ml、30.4±12.8pg/ml)为高(P<0.01)。结论男性不育与支原体感染密切相关;IL-4和IFN-γ检测有助于男性不育症支原体感染与否的诊断和治疗。Objective To investingate the relation between mycoplasma infection and IL-4, IFN γ of seminal plasma in infertile males. Methods Culture technique was applied to know the situation of mycoplasma infection. The levels of IL-4 and IFN γ were measured by ABC-ELISA. Results Of 31 patients, 20 cases infected with mycoplasma. The levels of IL-4 and IFN-γ of the infertile patients infected mycoplasma were 7.8±0.9pg/ml and 49.1±16.4pg/ml respectively. The rate of mycoplasma infection and the levels of IL-4 and IFNY of the cases infected mycoplasma was obviously higher than those of normal fertile group (3.4±1.62pg/ml and 30.4±12.8pg/ml). Conclusions The infectile males may be related to mycoplasma infection. IL-4 and IFN-γ delections are helpful to clinical diagnosis and treatmant for infertile males.

关 键 词：支原体感染 男性 不育 白细胞介素4 干扰素-Γ 

分 类 号：R446.62[医药卫生—诊断学] R375[医药卫生—临床医学] R256.56