封闭群东方田鼠的病理生物学特征观察  

An Investigation of Bio-pathologic Changes in Closed Breeding Microtus fortis

作　　者：俞远京 苏志杰 丁志刚 周智君 马亚东 彭兴华[2] 

机构地区：[1]中南大学湘雅医学院实验动物学部,长沙410078 [2]中南大学湘雅医学院分子生物学研究中心,长沙410078

出　　处：《实验动物科学》2003年第z1期142-143,共2页Laboratory Animal Science

摘　　要：The bio pathological changes in the closed breeding Microtus fortis (as a laboratory animal) were observed. Forty six cases of Microtus fortis were divided into 3 different age groups, and investigated by the pathological technique combined with the electron microscopey. Results showed pathologic changes of closed breeding Microfus fortis were located mainly in liver and lung with close relation to aging. Eight types of pathological changes were found. There were breast carcinoma and cryptorechism in indivignal cases. The electron microscopic characteristics of the breast carcinoma were different from that of KM mouse. Therefore, for establishing a standardized laboratory animal, it is necessary to do pathological monitoring for Micritus fortis as a routine, and then in term of the results of which the germs may be screened.The bio pathological changes in the closed breeding Microtus fortis (as a laboratory animal) were observed. Forty six cases of Microtus fortis were divided into 3 different age groups, and investigated by the pathological technique combined with the electron microscopey. Results showed pathologic changes of closed breeding Microfus fortis were located mainly in liver and lung with close relation to aging. Eight types of pathological changes were found. There were breast carcinoma and cryptorechism in indivignal cases. The electron microscopic characteristics of the breast carcinoma were different from that of KM mouse. Therefore, for establishing a standardized laboratory animal, it is necessary to do pathological monitoring for Micritus fortis as a routine, and then in term of the results of which the germs may be screened.

关 键 词：东方田鼠 病理生物学 观察 

分 类 号：N[自然科学总论]