hs-CRP、IL-6、TNF-α在心血管疾病中的意义  

The clinical significance of serum,hs-CRP,IL-6 and TNF-α in angiocardiopathy

作　　者：迟小伟[1] 刘杰[2] 

机构地区：[1]山东中医药大学附属医院检验科,济南250012 [2]济南市中心医院医学实验诊断中心,济南250013

出　　处：《医学检验与临床》2008年第3期50-51,共2页Medical Laboratory Science and Clinics

摘　　要：目的探讨hs-CRP、IL-6、TNF-α水平在心血管疾病发生及判断预后中的意义。方法采用酶联免疫吸附法(ELISA)检测132例健康体检者hs-CRP、IL-6、TNF-α水平,并进行随访,比较各细胞因子水平的高低在心血管疾病的发生预测中的意义。结果hs-CRP在充血性心力衰竭(Congestive Heart Failure,CHF)发生者高于未发生心脑血管疾病者(P<0.01);IL-6、TNF-α在冠心病、脑卒中、CHF发生者高于未发生心脑血管疾病者(P<0.01)。结论血清超敏CRP、IL-6和TNF-α水平对于临床估计心血管疾病的发生及判断预后具有重要的意义。Objective To investigate the clinical significance of serum value of hs-CRP,IL-6 and TNF-α in prediction and prognosis of angiocardiopathy. Methods 132 normal persons were studied.All the serum hs-CRP,IL-6 and TNF-α were detected by enzyme linked immunosorbent assay(ELIA),and these persons were followed up to investigate the relationship between the serum value in prediction of angiocardiopathy.Results The serum value of hs-CRP in CHF happened later is higher than not(P<0.01);The serum value of IL-6 and TNF-α in coronary,cerebrovascular disorder and CHF happened later is higher than not(P<0.01).Conclusion Detecting the serum value of hs-CRP,IL-6 and TNF-α has important significance in prediction and prognosis of angiocardiopathy.

关 键 词：HS-CRP IL-6 TNF-Α 心血管疾病 

分 类 号：R54[医药卫生—心血管疾病]