系统性红斑狼疮抗活化的蛋白C研究  

Study of activated protein C-resistance in systemic lupus erythematosus

作　　者：沈明[1] 林浩杰[2] 石晓红[1] 

机构地区：[1]山东省千佛山医院,山东济南250014 [2]济南市血液中心,山东济南250014

出　　处：《医学检验与临床》2008年第4期14-16,共3页Medical Laboratory Science and Clinics

摘　　要：目的了解抗活化的蛋白C(APCR)在系统性红斑(SLE)患者中的发生情况,并进一步探讨SLE患者发生血栓的机制。方法采用APG-KPTT法,ELISA法和PTT-LA法分别对36例SLE患者及20例正常对照(NC)进行APCR、抗心磷脂抗体(ACA)和狼疮抗凝物(LA)检测。结果SLE患者APCR阳性率(58%)明显高于NC组(5%)(P<0.005),APCR阳性患者中血栓发生率(27.6%)明显高于APCR阴性患者(4.8%)(P<0.01),患者LA阳性率(22%)明显高于对照组(0/10)(P<0.05),患者ACA-IgG及IgM明显高于对照组(P<0.05),而IgA与对照组差异不显著(P>0.05),LA阳性组中的APCR阳性率(90.9%)明显高于LA阴性组(53.8%)(P<0.05),ACA阳性组中的APCR阳性率(64.7%)与ACA阴性组(60.6%)未发现明显相关性(P>0.05)。结论APCR在国人SLE患者中有较高的发生率且与LA有明显相关性。APCR可能是SLE患者诱发血栓的主要原因之一。Objective To know the occurrence of activated protein C resistance(APCR)in Chinese patients with systemic lupus erythematosus(SLE)and investigate the occurring mechanism of thrombosis in SLE.Methods APC-KPTT assay,ELISA and PTT-LA methods were used respectively to detect APCR,anticardiolipin antibodies(ACA)and lupus anticoagulants(LA)in 36 patients with SLE and 20 normal controls(NC).Results The incidence of APCR in SLE(58%)was significantly higher than that in NC group(5.0%)(P<0.005),the incidence of thrombosis in APCR-positive(27.6%)was signify-cantly higher than in APCR-negative(4.8%)(P<0.05),the incidence of LA in SLE(22%)was significantly higher than in NC group(0/20)(P<0.05)and the ACA-IgG and IgM in SLE was higher than in NC group(P<0.05),but there was no significant difference of ACA-IgA between two groups(P>0.05),the incidence of APCR in LA-positive(90.9%)was obviously higher than in LA-negative(53.8%)samples of patients with SLE(P<0.05),but the ACA was not significantly associated with APCR(P>0.05).Conclusion There is a few higher incidence with APCR in Chinese patients with SLE and related to LA.APCR seems to be one of the main reasons to induce the thrombosis in patients with SLE.

关 键 词：红斑狼疮 系统性 抗体 抗磷脂 血栓形成 抗活化的蛋白C 

分 类 号：R593.241[医药卫生—内科学]