前S1抗原作为乙肝病毒复制指标的临床应用价值  

Clinical application value of Pre S1 antigen as a marker for replication for HBV

作　　者：焦付丰[1] 陈振祥[1] 

机构地区：[1]高唐县人民医院检验科,山东高唐252800

出　　处：《医学检验与临床》2008年第4期59-60,共2页Medical Laboratory Science and Clinics

摘　　要：目的观察前S1抗原(PreS1Ag)作为乙肝病毒复制指标的临床应用价值。方法对462名慢性乙型肝炎患者用ELISA法检测PreS1Ag和血清HBV标志物(HBV-M),用荧光定量PCR法测定HBV-DNA含量。结果462例HBsAg阳性患者中PreS1Ag阳性304人,阳性率65.8%,显著高于HBeAg阳性率(34%)(P<0.01)。HBsAg、HBeAg、HBcAb阳性组PreS1Ag阳性率为79.1%,HBsAg、HBeAb、HBcAb阳性组PreS1Ag阳性率为44.1%,两组差异有显著性(P<0.01)。PreS1Ag阳性率与HBV-DNA阳性率高度符合,阳性符合率达80%。结论前S1抗原能够敏感地反映乙型肝炎病毒复制情况,尤其可以反映HBeAg阴性患者是否有病毒复制。是对乙肝病毒标志物的有益补充,可作为临床常规检测指标。Objective To observes the clinical application value of Pre S1 antigen(Pres1Ag) as Marker for Replication of HBV.Methods The Pres1Ag,HBV-M were measured with EIA;HBV-DNA was measured with PCR in462 cases of chronic hepatitis B.Results Compared with HBeAg posetive rate(34%),Pres1Ag positive rate(65.8%) Significantly increased in HBsAg positive grorp (P<0.01).The posetive rate of PreS1Ag were 79.1% in HBsAg、HBeAg、HBcAb positive grorp;And in HBsAg、HBeAb、HbcAb positive grorp were 44.1%.There was a Significantly difference between them(P<0.01).Pre-S1 antigen and HBV-DNA have a higher positive coincidence rate.the coincidence rate reaches 80%.Conclusions Pre-S1 antigen has a higher sensitivity for hepatitis B virus replication. Especially may reflect whether the HBeAg negative patient does have the viral duplication.Pre-S1 detection,is a useful supplement for hepatitis B virus markers.It may take the clinical conventional examination target.

关 键 词：前S1抗原 乙型肝炎病毒 复制 指标 临床 应用价值 

分 类 号：R512.6[医药卫生—内科学]