干酪乳杆菌对免疫效应细胞杀伤作用影响的研究  

The Efftcts of Lactobacillus on The Killing Abilities of Natural Killing Cell

作　　者：姜国湖 董全江 纪令士 

机构地区：[1]青岛市海慈医疗集团临床检验中心,山东青岛266033

出　　处：《医学检验与临床》2008年第5期7-8,共2页Medical Laboratory Science and Clinics

摘　　要：目的研究干酪乳杆菌对自然杀伤细胞杀伤肿瘤细胞活性的影响。方法干酪乳杆菌与结肠癌细胞系HT-29细胞37℃5%CO2环境中共同孵育12h,应用MTT法检测NK细胞对HT-29细胞的杀伤活性。结果干酪乳杆菌作用HT-29细胞明显增强NK对其杀伤活性。结论该研究为益生菌抗肿瘤作用的研究提供了新的依据。Objective The study was to investigate the effect of Lactobacillus casei on NK killing abilities on human colon cancer cell lines HT-29. Method Lactobacillus casei and HT-29 in 5%CO2 humid atmosphere 37℃cultured for 12hrs, the killing abilities of immunocompetent cells NK were observed by the method of MTT. Results The experimental result shows, Lactobacillus casei can strengthen the killing abilities of NK cell. Conclusion The experimental result offer the new basis for further investigating the antitumorous features of probiotics.

关 键 词：干酪乳杆菌 NK细胞 杀伤活性 

分 类 号：R392[医药卫生—免疫学]