直链烷基修饰对Gd-DTPA的稳定性和质子弛豫性能的影响  

Effects of Modifying Gd-DTPA by Linear Chain Alkyl Group on Its Stability Constant and the Water Proton Relaxivity

作　　者：冯志明[1] 李旭红[2] 李峰[1] 雷春华[1] 

机构地区：[1]湖南师范大学化学化工学院,湖南长沙410081 [2]中南大学湘雅三医院,湖南长沙410013

出　　处：《湖南师范大学学报（医学版）》2006年第3期22-24,共3页Journal of Hunan Normal University(Medical Sciences)

基　　金：湖南省教育厅资助科研项目(04C346)

摘　　要：目的:探讨直链烷基修饰对Gd-DTPA稳定性和水质子弛豫性能的影响。方法:采用配位竞争法测定钆螯合物的稳定常数,采用反转恢复法测定钆螯合物的水质子弛豫时间。结果:Gd-α-癸基-DTPA和Gd-α-十四烷基-DTPA的稳定常数(lg K)分别为22.80和22.75,生理PH条件下对水质子的弛豫率(R1)分别为4.86和4.78。结论:与母体化合物(Gd-DTPA)比较,Gd-α-癸基-DTPA和Gd-α-十四烷基-DTPA仍保持高稳定性和强的水质子弛豫性能。Objective To investigate the effect of modifying Gd-DTPA by alkyl group on its stability and proton relaxivity of Gd-DTPA.Methods The stability constants of gadolinium chelates were determined by using a compitition method and water proton ralaxation times T1 were measured by means of the inversion recovery method.Results The stability constants of Gd-α-decyl-DTPA和 Gd-α-tetradecyl-DTPA(lg K)are 22.80 and 22.75 respectively,the water proton relaxivities of Gd-α-decyl-DTPA和 Gd-α-tetradecyl-DTPA(R1) are 4.86和4...

关 键 词：钆螯合物 稳定性 质子弛豫 

分 类 号：R91[医药卫生—药学]