双白术内酯对三氯化铝致痴呆模型小鼠的作用研究  

Effects of Biatractylolide on the AD Rats Induced by AlCl_3

作　　者：刘洋[1] 廖春梅[2] 

机构地区：[1]湖南师范大学医学院2002级药学专业本科班,湖南长沙410006 [2]湖南师范大学医学院,湖南长沙410006

出　　处：《湖南师范大学学报（医学版）》2006年第3期25-26,30,共3页Journal of Hunan Normal University(Medical Sciences)

摘　　要：目的:探讨双白术内酯抗老年性痴呆的作用机制。方法:用水迷宫法检查学习、训练结果;行为学实验结束后小鼠断颈椎处死,取脑组织,匀浆,比色法测乙酰胆碱酯酶含量,观察双白术内酯对记忆障碍模型小鼠的影响。结果:显示双白术内酯能有效降低三氯化铝致痴呆模型小鼠脑内胆碱酯酶活性,提高痴呆小鼠的记忆能力。结论:双白术内酯可改善三氯化铝致痴呆模型小鼠的学习记忆能力,并显著性降低脑内乙酰胆碱酶水平。Objective To investigate the effects of biatractylolide on AD rats induced by AlCl_3.Methods The ability of remembering of mice was studied by the water maze method.After mice sentenced death,we took off the brain,and measured the AchE content through the method of colorimetry.Results Biatractylolide could improve the memory function of the AD rats induced by AlCl_3,and reduce the AchE activity in the brain.Conclusion Biatractylolide could improve the studying memory of the AD rats induced by AlCl_3 and red...

关 键 词：双白术内酯 学习 记忆 小鼠 

分 类 号：R285[医药卫生—中药学]