中年男性2型糖尿病患者性激素水平与颈动脉内膜中层厚度的关系  

Relationship Between Sex Hormones Levels and Carotid Intima-Media Thickness in the Middle-Aged Men with Type 2 Diabetes Mellitus

作　　者：徐爱霞[1] 唐莉[1] 王晓华[1] 李方雄[2] 

机构地区：[1]长沙市中心医院内分泌科,湖南长沙410005 [2]中南大学湘雅医院心内科,湖南长沙410008

出　　处：《湖南师范大学学报（医学版）》2008年第4期33-36,共4页Journal of Hunan Normal University(Medical Sciences)

摘　　要：目的:分析糖尿病患者性激素水平及颈动脉内膜中层厚度(IMT),研究性激素水平及与IMT之间的关系。方法:对100例中年男性糖尿病患者和100例中年健康男性(作为对照组)采集其晨起静脉血,低温离心后取血清,测定总睾酮、游离睾酮(FT)、脱氢表雄酮硫酸酯(DHEAS)、性激素结合球蛋白(SHBG)、雌二醇、黄体生成素(LH)、卵泡刺激素(FSH)水平,并行颈动脉超声检查,测定内膜中层厚度平均值及斑块厚度,并行血糖及血脂等检查。结果:(1)糖尿病患者总睾酮、FT、DHEAS明显降低(P<0.01),SHBG水平显著增加(P<0.01)。(2)糖尿病患者内膜中层较对照组明显增厚(P<0.05),斑块检出率显著增高(P<0.05)。(3)FT水平与IMT呈显著负相关(r=-0.516,P=0.023)。结论:中年男性2型糖尿病患者雄激素水平显著降低,且FT水平与IMT呈负相关。Objective To study the relationships between sex hormones levels and carotid intima-media thickness(IMT) in middle-aged men with type 2 diabetes.Methods One hundred male patients diagnosed type 2 diabetes clinically aged from 40 to 60 were selected in this study.One hundred middle-aged healthy men were studied as Control.Blood samples were collected in the morning and TT,FT,DHEAS,SHBG,E2,LH,FSH were measured.All men,IMT and plaques were analysed by altrasound.Results The levels of TT,FT and DHEAS were decre...

关 键 词：糖尿病 内膜中层厚度 附睾分泌蛋白质类 超声 

分 类 号：R587.1[医药卫生—内分泌]