One-pot tandem Barbier-Prins synthesis of tetrahydropyrans in aqueous media  

作　　者：WEN Meijiao TANG Long CHANG Weixing LI Jing 

机构地区：[1]State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China

出　　处：《Science China Chemistry》2005年第1期38-41,共4页中国科学（化学英文版）

基　　金：the Key Foundation of the Ministry of Education of China ; National Natural Science Foundation of China(Grant No.20372033).

摘　　要：By investigating the effect of the amount of water, the ratio of aldehyde and allyl- bromide, and the reaction temperature on the transformation, 2,4,6-trisubstituted tetrahydro- pyrans are synthesized by a novel tandem Barbier-Prins-cyclization reaction in the presence of micro-amount of water under mild conditions. The experiment is easy to perform without the need to exclude moisture or air. The reaction is atomic economical and environmentally benign.By investigating the effect of the amount of water, the ratio of aldehyde and allyl- bromide, and the reaction temperature on the transformation, 2,4,6-trisubstituted tetrahydro- pyrans are synthesized by a novel tandem Barbier-Prins-cyclization reaction in the presence of micro-amount of water under mild conditions. The experiment is easy to perform without the need to exclude moisture or air. The reaction is atomic economical and environmentally benign.

关 键 词：Barbier-type  Prins-cyclization  tetrahydropyran  water  environment benign. 

分 类 号：N[自然科学总论]