Study on the interactions between anti-tumor metal complexes and mononucleotides using trans-[en_(2)Os(h^(2)-H_(2))(CF_(3)SO_(3))](CF_(3)SO_(3))as a^(1)H NMR probe in a competitive mode  

作　　者：YANG Pin CHEN Huili FAN Yingfang YUE Lijun MENG Xiangli 

机构地区：[1]Institute of Molecular Science,Chemical Biology and Molecular Engineering Laboratory of Education Ministry,Shanxi University,Taiyuan 030006,China

出　　处：《Science China Chemistry》2005年第3期227-239,共13页中国科学(化学英文版)

基　　金：the National Natural Science Foundation of China(Grant No.20171031);Provincial Natural Foundation of Shanxi.

摘　　要：The interaction of several anti-tumor metal complexes with dGMP have been investigated using trans-[en_(2)Os(h^(2)-H_(2))]^(2+)as a ^(1)H NMR probe in a competitive mode.Me_(2)SnCl_(2),Bu_(2)SnCl_(2),Et_(2)Sn(phen)Cl_(2) and Et_(2)SnCl_(2) can bind to dGMP mainly via phosphate;Cp_(2)TiCl_(2) binds to dGMP mainly via phosphate and N_(7).The binding constant for(CH_(3))_(2)SnCl_(2) binding to phos-phate of dGMP exceeds 2.71×10^(4).The binding constant for Cp_(2)TiCl_(2) to phosphate is even greater than that of Sn(IV).Cis-platin has high affinity for both N_(7) and phosphate,but mainly for N_(7).Binding of the probe to N_(7) of dGMP reduces the binding affinity for phosphate of the same dGMP molecule by a factor of 5 to 6.Much the same factor is expected to apply to other metals containing agents interacting with dGMP.

关 键 词：trans-[en_(2)Os(h^(2)-H_(2))]^(2+) dGMP anti-tumor metal complex competitive mode. 

分 类 号：N[自然科学总论]