Synthesis and relaxivity of Gd(Ⅲ), Fe(Ⅲ) and Mn(Ⅱ) complexes with dihydropyridine derivative of diethvlenetriaminepentaacetic acid  

作　　者：CHANG Jianhua ZHENG Shuzhan JIAN Yajun BAI Yinjuan ZHANG Shiping 

机构地区：[1]Department of Chemistry, Northwest University, Xi'an 710069, China Department of Chemistry, Northwest University, Xi'an 710069, China Department of Chemistry, Northwest University, Xi'an 710069, China Department of Chemistry, Northwest University, Xi'an 710069, China Department of Chemistry, Northwest University, Xi'an 710069, China

出　　处：《Science China Chemistry》2005年第z1期93-96,共4页中国科学（化学英文版）

摘　　要：A novel ligand of DTPA-dihydropyridine derivative was synthesized by reaction of DTPA-dianhydride with 4-aniline-1,4-dihydropyridine. Its complexes of gadolinium, manganese and iron were prepared. Their spin-lattice relaxivities (T1) were investigated. The results show that the NMR T1 relaxivitives (R1) for complexes of Fe(Ⅲ), Mn(Ⅱ) are less than that of Gd(Ⅲ) complex,which has a high relaxivity (R1) on the surrounding water protons, indicating that the Gd(Ⅲ) complex possesses the precondition to be contrast agents for magnetic resonance imaging.A novel ligand of DTPA-dihydropyridine derivative was synthesized by reaction of DTPA-dianhydride with 4-aniline-1,4-dihydropyridine. Its complexes of gadolinium, manganese and iron were prepared. Their spin-lattice relaxivities (T1) were investigated. The results show that the NMR T1 relaxivitives (R1) for complexes of Fe(Ⅲ), Mn(Ⅱ) are less than that of Gd(Ⅲ) complex, which has a high relaxivity (R1) on the surrounding water protons, indicating that the Gd(Ⅲ) complex possesses the precondition to be contrast agents for magnetic resonance imaging.

关 键 词：diethylenetriaminepentaacetic acid  dihydropyridine  magnetic resonance imaging CONTRAST agent  relaxivity. 

分 类 号：N[自然科学总论]