乌司他丁在急诊体外循环下冠状动脉搭桥术中的心肌保护作用  

Protecting Effects of Ulinastatin in Patients Undergoing Emergency on-pump Coronary Artery bypass Surgery

作　　者：徐忠东[1] 何伟雄[2] 金沐[3] 赵一凡[1] 夏淑轩[1] 何波[1] 杨涛[1] 曹德雄[1] 彭书峻[1] 李珏[1] 曹铭辉[1] 

机构地区：[1]中山大学附属第二医院麻醉科,510120 [2]中山大学附属肿瘤医院麻醉科 [3]中国医学科学院中国协和医科大学阜外心血管病医院麻醉科

出　　处：《岭南急诊医学杂志》2009年第3期164-165,共2页Lingnan Journal of Emergency Medicine

摘　　要：目的:探讨乌司他丁在急诊体外循环下冠状动脉搭桥术(CABG)中的心肌保护作用。方法:将24例行急诊CABG的冠心病患者随机分为对照组(C组)和乌司他丁组(U组)。U组:气管插管后开始恒速静脉泵入7500 u/kg的乌司他丁,30 min泵完,C组则泵注同样容积的生理盐水。分别在术前、术毕2 h、6 h、24 h测定血浆cTnI水平。结果:各组内术后cTnI水平均明显增高(P<0.05),U组术后cTnI水平显著低于C组(P<0.05)。结论:乌司他丁可降低急诊CABG患者围术期cTnI水平,对心肌损伤具一定的保护作用。Objective:To investigate the protective effect of Ulinastatin against myocardial injury in patients undergoing emergency on-pump coronary artery bypass surgery(CABG).Methods:24 patients undergoing CABG were randomly divided into two equal groups(n=12):Ulinastatin group in which Ulinastatin was infused intravenously at the concentration of 7500 u/kg dissolved in 50 mL normal saline for 30 min and control group that underwent infusion of normal saline of the same volume.Blood samples were obtained prior of the operation and at the 0 h,2 h,6 h,24 h after the end of the operation.The serum cTnI were determined.Results:In both groups,the cTnI levels were significantly increased at the post-operative (2 h,6 h,24 h) compared with those before the operation (P<0.05).The cTnI levels of U-group were markedly decreased compare with those of C-group after the operation (P<0.05). Conclusion:Ulinastatin decreases the cTnI levels induced by CABG,so reducing the risk of myocardial injury.

关 键 词：心肌肌钙蛋白Ⅰ 急诊 体外循环冠状动脉旁路移植术 心肌再灌注损伤Ⅰ 

分 类 号：R654.2[医药卫生—外科学]