KAI1/CD82和E-cadherin在子宫内膜癌的表达  

Expression of KAI1/CD82 and E-cadherin in Endometrial Carcinoma

作　　者：黄筱竑[1] 章彤华[1] 平金良[1] 袁慧琴[1] 

机构地区：[1]湖州市中心医院,浙江湖州313000

出　　处：《肿瘤学杂志》2009年第9期855-858,共4页Journal of Chinese Oncology

摘　　要：[目的]研究KAI1/CD82与E-cadherin在子宫内膜癌组织中的表达及其与临床病理参数的关系。[方法]采用免疫组织化学EnVision二步法检测76例子宫内膜癌,15例非典型增生子宫内膜和20例正常增生期子宫内膜组织中KAI1/CD82、E-cadherin的表达。[结果]KAI1/CD82在正常增生期子宫内膜、非典型增生内膜、子宫内膜癌的阳性表达率分别为95%、93.3%和60.5%;E-cadherin在正常增生期子宫内膜、非典型增生内膜、子宫内膜癌的异常表达率分别为0、6.67%和55.26%。KAI1/CD82在子宫内膜癌的表达与组织学分级、肌层浸润程度呈负相关(P=0.000,P=0.01)。E-cadherin在子宫内膜癌的表达与组织学分级及组织学类型有关。KAI1/CD82与E-cadherin在子宫内膜癌中的表达呈显著性相关(P<0.01)。[结论]KAI1/CD82表达下调和E-cadherin异常表达增高与子宫内膜癌的进展有关。[Purpose] To investigate expression of KAI1/CD82 and E-cadherin in endometrial carcinoma, and its correlation with clinicopathological features. [Methods] Expression of KAI1/CD82 and E-cadherin in 76 cases with endometrial carcinoma, 15 cases with uterine atypical endometrial hyperplasia and 20 cases with normal proliferative phase endometrium were detected immunohistochemically. [Results] The expression rate of KAI1/CD82 in normal proliferative phase endometrium, in atypical endometrial hyperplasia and in ...

关 键 词：KAI1/CD82 E-CADHERIN 免疫组织化学 子宫内膜肿瘤 

分 类 号：R737.33[医药卫生—肿瘤]