改良缺血修饰性白蛋白测定法在诊断早期心肌梗死中的应用  

Clinical value of an improved ischemia-modified albumin assay in the diagnosis of early acute myocardial infarction

作　　者：陈志晓[1] 王前[1] 郑磊[1] 包杰[1] 

机构地区：[1]南方医科大学南方医院检验科,广东广州510515

出　　处：《南方医科大学学报》2009年第7期1378-1380,共3页Journal of Southern Medical University

基　　金：广东省科技计划项目(2006B1290121)

摘　　要：目的评价改良缺血修饰性白蛋白(IMA)测定方法对心肌梗死的早期诊断价值。方法研究84例胸痛病人,其中确诊急性心肌梗死病人43例,胸痛对照组41例,所有病人均在发病6h内抽血,用改良钴-白蛋白结合法测定缺血修饰性白蛋白,结果用吸光度大小表示;利用ROC曲线来评价IMA诊断AMI的阀值。结果AMI组IMA吸光度值为(1.195±0.320),胸痛组IMA吸光度为(0.855±0.068),两组差异显著(P<0.001)。ROC曲线下的面积为0.947,当阀值为0.906时,其诊断敏感度为93.0%,诊断特异度82.9%。结论利用改良方法测定IMA对急性心肌梗死的早期诊断具有一定的应用价值。Objective To assess the value of an improved ischemia modified albumin(IMA) assay in the diagnosis of early acute myocardial infarction(AMI).Methods Forty-three patients with AMI were enrolled in this study with 41 patients with chest pain serving as the control.Blood samples were obtained from all the patients within 6 h after the onset.IMA was measured by the albumin cobalt binding test and results were presented by absorbance units(ABSU).Receiver operator characteristic curve(ROC curve) was used to evalu...

关 键 词：缺血修饰性白蛋白 急性心肌梗死 1-亚硝基-2-萘酚 白蛋白-钴结合实验 二硫苏糖醇 

分 类 号：R542.22[医药卫生—心血管疾病]