扩散加权成像诊断缺氧缺血性脑病最佳时间窗的研究  

The diagnosis study of hypoxic-ischemic encephalopathy using MR diffusion weighted imaging

作　　者：马得廷[1] 孔庆奎[1] 张有军[1] 张立涛[1] 韩耀启[1] 

机构地区：[1]泰山医学院附属泰安医院,山东泰安271000

出　　处：《泰山医学院学报》2009年第11期820-823,共4页Journal of Taishan Medical College

摘　　要：目的探讨扩散加权成像(DWI)诊断缺氧缺血性脑病(HIE)的最佳时间窗。方法对临床确诊的81例HIE患儿(年龄12h至38 d,平均11.49 d;男63例,女18例)行常规T1WI、T2WI和DWI检查(b=1000 s/mm2),分为5组[Ⅰ组(≤4d)20例、Ⅱ组(5~7d)12例、Ⅲ组(8~14d)23例、Ⅳ组(15~21d)18例和Ⅴ组(≥22d)8例]。在DWI、T1WI上观察比较皮层及皮层下白质、深部白质、基底节及丘脑、脑室及脑外间隙等部位病灶数目、范围、清晰度,并进行独立样本t检验。结果在显示病灶数目、大小和清晰度方面:I组中DWI均明显优于T1WI(P值均<0.01);Ⅱ、Ⅲ组中DWI和T1WI均无明显统计学差异(P值均>0.05);Ⅳ、Ⅴ组中DWI均不及T1WI(P值均<0.05)。结论DWI在HIE不同时期的诊断价值不同,4天内是DWI诊断HIE的最佳时间窗。Objective:To assess the value of the diffusion weighted imaging(DWI) in different phase of Hypoxic-ischemic Encephalopathy(HIE).Methods: 81 cases of HIE by clinical diagnosis were selected as subjects.Of 81 cases,63 were male and 18 female,the age ranging from 12 hours to 38 days,with an average age of 11.49 days.All patients had undergone T 1WI,T 2WI and DWI(b=1000s/mm2) examination,which were divided into five groups[I group(≤4 days),20 cases;II group(5~7 days),12 cases;III group(8~14 days),23 cases;IV gr...

关 键 词：缺氧 脑 新生儿 磁共振成像 扩散加权像 时期 

分 类 号：R722.121[医药卫生—儿科] R445.2[医药卫生—临床医学]