反药“乌头半夏散”镇痛及皮肤急性毒性实验研究  

Experimental Study on Analgesic Action and Dermal Acute Toxicity of Incompatible Medicaments(Wutoubanxiasan)

作　　者：龚可[1] 张世俊[2] 何光星[3] 王茄 魏建军[4] 毛毅[1] 

机构地区：[1]四川省成都市中西医结合医院,610017 [2]四川省中医药科学院针灸经络研究所,成都610031 [3]四川省中医药科学院中药研究所,成都610041 [4]中国医学科学院输血研究所,成都610081

出　　处：《黑龙江中医药》2009年第4期39-41,共3页Heilongjiang Journal of Traditional Chinese Medicine

基　　金：四川省中医药管理局科研基金资助(编号:2003A02)

摘　　要：目的:观察乌头半夏散镇痛作用和皮肤急性毒性、皮肤刺激性、致敏性。方法:用乌头半夏散和对照药(相同处方但缺半夏)"缺半夏散",采用小鼠醋酸扭体法;家兔皮肤局部吸收急性毒性试验:豚鼠过敏试验。结果:乌头半夏散对醋酸扭体有非常明显抑制作用(P<0.01),与对照组比较有显著性差异(P<0.05);对家兔皮肤局部吸收急性毒性试验、体重两药均无明显毒性及影响;乌头半夏散对豚鼠无致敏性;对照药对豚鼠有轻度致敏性。结论:乌头半夏散有明显的镇痛作用优于非反药"缺半夏散",且无明显急性毒性和致敏性,并提示反药乌头半夏配伍外用有提高镇痛作用和抑制皮肤急性毒性作用。Obective:to investigate analgesic actions,dermal acute toxicity,skin irritation and skin sensitization of Wutoubanxiasan.Methods:The animals were randomly assigned to treatment group which received Wutoubanxiasan and the control group which received the similar prescription free of Pinellia Ternate.The results were concluded from acetic acid writhing test on mice,skin absorption test on rabbits and kin sensitization test on Guinea pigs.Results:In acetic acid writhing test on mice, Wutoubanxiasan inhibited t...

关 键 词：反药 乌头半夏散 镇痛实验 皮肤急性毒性实验 

分 类 号：R285.5[医药卫生—中药学]