生长分化因子-15的心血管作用  

Cardiovascular Effect of Growth Differentiation Factor 15

作　　者：梁瀛[1] 牛杰[1] 高炜[1] 

机构地区：[1]北京大学第三医院心内科,北京100191

出　　处：《心血管病学进展》2009年第6期934-938,共5页Advances in Cardiovascular Diseases

摘　　要：生长分化因子-15是转化生长因子β超家族的成员之一。近年来有实验室研究发现,生长分化因子-15在心肌缺血或缺血/再灌注损伤时可高表达,并减少心肌细胞坏死的数量,抑制缺血心肌细胞的凋亡。在心肌压力超负荷的情况下,生长分化因子-15高表达或给予外源性生长分化因子-15可抑制心肌肥厚及心脏扩大,保护心功能。而在临床研究中发现急性冠脉综合征和心力衰竭的患者生长分化因子-15增高,与部分心血管的危险因素存在相关性,对患者的预后有提示作用。Growth differentiation factor 15(GDF-15) is a member of the transforming growth factor-β superfamily.Recently experimental research has found that GDF-15 is highly expressed in myocardial ischemia or ischemia/reperfusion injury,which can reduce myocardial necrosis and apoptosis.In the condition of pressure overload,GDF-15 over expression,or exogenous GDF-15,can inhibit myocardial hypertrophy and dilation,appearing to have a cardio-protective effect.Some clinical studies show that the circulating level of GD...

关 键 词：生长分化因子-15 心肌缺血 缺血/再灌注 心力衰竭 

分 类 号：R54[医药卫生—心血管疾病]