Sca-1^+心肌干细胞的研究进展  

Advances in Research in Sca-1^+ Cardiac Stem Cells

作　　者：康振峻[1] 钟理[1] 宋治远[1] 

机构地区：[1]第三军医大学附属西南医院心血管内科,重庆400038

出　　处：《心血管病学进展》2009年第6期1047-1050,共4页Advances in Cardiovascular Diseases

摘　　要：干细胞抗原1(Sca-1)是干细胞的一种重要表面标记物,体内许多干细胞都表达Sca-1。同样,心肌干细胞也表达Sca-1。目前研究发现,Sca-1+心肌干细胞能够分化为心肌细胞,对心肌梗死后心室重构与心肌再生具有明显作用,能够促进心脏的修复。因此,Sca-1+心肌干细胞有可能使心肌梗死的临床治疗取得实质性的进展。现综述了Sca-1+心肌干细胞的来源、分化、作用等方面。Stem cell antigen-1(Sca-1) is an important surface marker for stem cells;cardiac myocytes,and other somatic stem cells express Sca-1.Recently,a number of reports have suggested that Sca-1+ cardiac stem cells were capable of differentiating into cardiac myocytes,which were significantly contributing to post myocardial infarction(post-MI) left ventricular remodeling and myocardium regeneration,and which could promote cardiac repair.Accordingly,Sca-1+ cardiac stem cells might lead to clinically useful therapie...

关 键 词：干细胞抗原1 心肌干细胞 分化 心肌细胞 

分 类 号：Q2[生物学—细胞生物学]