5-溴甲基-2(5H)-呋喃酮的生理活性初探  

The Studies of Biological Activities of 5-Bromomethyl-2(5H)-furanone

作　　者：董丽丽 金大成[1] 朴仁哲[2] 金仁君[3] 孙东植[3] 田官荣[1] 李熙峰[1] 

机构地区：[1]长白山生物功能因子省部共建教育部重点实验室延边大学,延吉133002 [2]延边大学农学院,龙井133400 [3]延边大学医学部,延吉133002

出　　处：《天然产物研究与开发》2010年第2期319-322,共4页Natural Product Research and Development

基　　金：吉林省科技厅2007年项目(20070557)

摘　　要：本文报道了原白头翁素衍生物5-溴甲基-2(5H)-呋喃酮的合成和抗癌活性及其抑制农作物病原菌活性的探讨结果,表明在5～20μg/mL范围内,5-溴甲基-2(5H)-呋喃酮对人肺癌A549细胞株有明显的抑制生长的作用;在50～200μg/mL范围内,其对玉米大斑病菌等的生长抑制率可达到95%以上。5-Bromomethyl-2(5H)-furanone was synthesized and its biological activities were tested in this paper.The MTT test showed that 5-bromomethyl-2(5H)-furanone in concentration of 0.25,5,10 μg/mL could inhibit the hyperplasy of A549 human lung cancer cells in a dosage–time-dependent manner.The growth of Exserohilum turcicum was inhibited completely in concentration of 50-200 μg/mL.

关 键 词：白头翁 原白头翁素 5-溴甲基-2(5H)-呋喃酮 肺癌A549细胞株 玉米大斑病菌 

分 类 号：S567.239[农业科学—中草药栽培]