黄腐酸的提取与其醒酒作用的研究  

Study on Extraction and Sober-up Effect of Fulvic Acid (FA)

作　　者：毕艳艳[1] 李宝才[1] 何静[1] 李月梅[1] 崔佳丽[1] 张水花[1] 梅展青[2] 

机构地区：[1]昆明理工大学生命科学与技术学院,昆明650224 [2]香港满好集团云南满好肥料有限公司,昆明650106

出　　处：《天然产物研究与开发》2010年第1期144-148,共5页Natural Product Research and Development

基　　金：企业联合开发项目(KKK0200826106);校人才培养基金(KK20200726038)

摘　　要：提取制备黄腐酸(FA)并研究其醒酒作用及部分作用机制,对昆明小鼠预防性灌胃不同浓度的黄腐酸,观察小鼠的醉酒时间和醉酒小鼠的只数,并使用气相色谱仪(GC)测定小鼠血浆中乙醇的浓度。结果:与模型组相比,3%、5%黄腐酸组中小鼠醉酒时间明显缩短(P<0.05);与海王金樽组相比,1%、3%、5%黄腐酸组中小鼠醉酒时间均明显缩短(P<0.05),且5%黄腐酸的醒酒防醉效果最佳。与模型组相比,30、90min时,1%、5%黄腐酸组中小鼠血浆中乙醇浓度明显降低(P<0.05);60min时,乙醇浓度降低非常明显(P<0.01)。与海王金樽组相比,60、90min时,1%、5%黄腐酸组中小鼠血浆中乙醇浓度明显降低(P<0.05)。黄腐酸具有醒酒作用,这为开发黄腐酸成为一种新型的醒酒药物提供了实验数据。Fulvic acid was extracted,and the sober-up effect of fulvic acid and the part of mechanism were investigated.Administrated the Kunming mice with the different concentration of fulvic acid previously,the drunken time of mice and the number of drunken mice were observed,and the ethanol concentration in the mice plasma was determined with gas chromatography(GS).Results:Compared with model group,the drunken time of mice with 3% and 5% fulvic acid given was shortened significantly(P<0.05);compared with King D...

关 键 词：黄腐酸 醒酒作用 气相色谱仪 海王金樽 

分 类 号：R285.5[医药卫生—中药学]