Endometrium implantation and ectopic pregnancy  

作　　者：LIU Yixun 

机构地区：[1]State Key Laboratory of Reproductive Biology,Institute of Zoology,Chinese Academy of Sciences,Beijing 100080,China

出　　处：《Science China(Life Sciences)》2004年第4期293-302,共10页中国科学（生命科学英文版）

基　　金：This work was supported by WHO/Rockefeller Foundation(RF96020#78);CONRAD/CICCR(CIG-01-71);CAS Chuangxi(KSCX-2-SW-201);'973'(G1999055901);National Natural Science Foundation of China(Grant Nos.39970284,90208025,30170452,30370200).

摘　　要：Embryo in uterine implantation is a complex and multifactor-related process and is a downstream and ideal point for woman fertility control. Understanding the cellular and molecular mechanism of implantation is a prerequisite for development of anti-implantation contraceptives. In spite of considerable accumulation of information from the laboratory animals that has been achieved, it is difficult to generate such information in human due to ethical restriction and experimental limitation, and the present knowledge for understanding the definitive mechanisms which control these events remains elusive. Embryo implantation can also occur outside uterus. Some women with abdominal pregnancies could successfully complete the processes of gestation and bear normal babies, implying that implantation itself may be not an endometrium-specific process. Reproductive biologists should cooperate with gynecologists to further comparatively study the molecular and cellular mechanisms of implantation normally occurring in endometrium and abnormally appearing outside uterine cavity. Such collaborative studies may generate new important information for developing anti-implantation contraceptive and for techniques of accurate diagnosis of ectopic pregnancy. A specially designed GnRH-2 analog and a combination use of low dose RU486 and gossypol as anti-implantation contraceptives have been suggested. Keywords embryo implantation - implantation window - materno-embryonic dialogue - ectopic pregnancyEmbryo in uterine implantation is a complex and rnultifactor-related process and is a downstream and ideal point for woman fertility control. Understanding the cellular and molecular mechanism of implantation is a prerequisite for development of anti-implantation contraceptives. In spite of considerable accumulation of information from the laboratory animals that has been achieved, it is difficult to generate such information in human due to ethical restriction and x-perimental limitation, and the present knowledge for understanding the definitive mechanisms which control these events remains elusive. Embryo implantation can also occur outside uterus. Some women with abdominal pregnancies could successfully complete the processes of gesta-tion nd bear normal babies, implying that implantation itself may be not an endo-metrium-specific process. Reproductive biologists should cooperate with gynecologists to further comparatively study the molecular and cellular mechanisms of implantation normally occurring in endometrium and abnormally appearing outside uterine cavity. Such collaborative studies may generate new important information for developing anti-implantation contraceptive and for tech-niques of accu- rate diagnosis of ectopic pregnancy. A specially designed GnRH-2 analog and a combination use of low dose RU486 and gossypol as anti-implantation contraceptives have been suggested.

关 键 词：EMBRYO implantation implantation window materno-embryonic dialogue ectopic pregnancy. 

分 类 号：N[自然科学总论]