电针对SAMP8小鼠海马神经元葡萄糖调节蛋白75的影响研究  

The Influence of electro-acupuncture Therapy on Grp75 of Hippocampal Neuron of SAMP8

作　　者：彭静[1] 曾芳[2] 何宇恒[2] 唐勇[2] 尹海燕[2] 余曙光[2] 

机构地区：[1]四川省乐山市中医院,四川乐山614000 [2]成都中医药大学,四川成都610075

出　　处：《针灸临床杂志》2010年第2期45-47,共3页Journal of Clinical Acupuncture and Moxibustion

基　　金：国家自然基金;30472235;四川省教育厅自然科学青年基金;2006B023

摘　　要：目的:观察电针对SAMP8小鼠海马神经元grp75的影响,从改善能量代谢障碍的角度探讨电针治疗阿尔茨海默病(AD)的部分作用机制。方法:采用计算机随机的方法,将SAMP8小鼠分为模型组、模针组;SAMR1小鼠作为空白组。电针'百会'、'涌泉'对模针组进行治疗,施以疏密波,频率2~100Hz,电压2~4 V。治疗结束后,用Morris水迷宫测试空间学习记忆能力的变化,评价电针对AD的治疗效应;用免疫组化方法检测grp75表达。结果:与模型组相比,模针组小鼠治疗后平均逃避潜伏期缩短,在原平台所在象限停留的时间延长(P<0.05);模针组小鼠海马神经元grp75较模型组表达增高(P<0.01)。结论:电针对SAMP8小鼠学习记忆能力的改善,可能与提高海马神经元grp75的表达、调节线粒体功能、改善能量代谢障碍有关。Objectivn:To reveal the influence of electro-acupuncture therapy on grp75 of hippocampal neuron of SAMP8 and partly explore the mechanism of electro-acupuncture therapy on Alzheimer s Disease.Methods:SAMP8 were divided into model group and electro-acupuncture group with the method of computer random and SAMR1 were taken as vacant group.SAMP8 were punctured on 'Baihui(Du20)' and 'Yongquan(Kidney1)'.The changes of learning and memory abilities were measured by Morris water maze test.The expressions of grp75 w...

关 键 词：SAMP8小鼠 阿尔茨海默病 GRP75 海马神经元 电针疗法 

分 类 号：R245[医药卫生—针灸推拿学]