Identification of Common Variants within KCNK17 in Chinese Han Population  

作　　者：唐洲平 丁虎 徐宇军 徐沙贝 

机构地区：[1]Department of Neurology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology [2]The Institute of Hypertension and Department of Internal Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology

出　　处：《Journal of Huazhong University of Science and Technology(Medical Sciences)》2010年第1期13-17,共5页华中科技大学学报（医学英德文版）

基　　金：supported by grants from National Nature Science Foundation Committee of China(No.30600187,No.30770751)

摘　　要：KCNK17 is a member of the acid-sensitive subfamily of tandem pore K+ channels,which are open at all membrane potentials and contribute to cellular resting membrane potential.Recent genome-wide study(GWA)has shown that variants within KCNK17 confer genetic susceptibility for increasing ischemic stroke.In an effort to discover additional polymorphism(s),we scrutinized the genetic polymorphisms in the KCNK17.By direct DNA sequencing in 32 individuals,we identified nine sequence variants within the 16kb of whol...KCNK17 is a member of the acid-sensitive subfamily of tandem pore K+ channels,which are open at all membrane potentials and contribute to cellular resting membrane potential.Recent genome-wide study(GWA)has shown that variants within KCNK17 confer genetic susceptibility for increasing ischemic stroke.In an effort to discover additional polymorphism(s),we scrutinized the genetic polymorphisms in the KCNK17.By direct DNA sequencing in 32 individuals,we identified nine sequence variants within the 16kb of whol...

关 键 词：POLYMORPHISM haplotypes KCNK17 ischemic stroke Chinese Han population 

分 类 号：Q987[生物学—遗传学]