以~1HNMR为实验手段观察不同pH条件对阿司匹林结构的影响  

Effect of Different pH on the Solubility and Structure of Aspirin Observed by Using ~1H-nuclear Magnetic Resonance

作　　者：郑美青[1] 王玉记[1] 吴建辉[1] 张进禄[1] 

机构地区：[1]首都医科大学现代药学实验与测试室

出　　处：《首都医科大学学报》2010年第2期255-257,共3页Journal of Capital Medical University

摘　　要：目的小剂量阿司匹林作为药物研发中体内抗血栓模型和体外抗血小板聚集模型的阳性药,在0.9%氯化钠注射液中溶解度很低,本文主要是以磁共振技术为实验手段研究不同pH条件对阿司匹林结构的影响。方法为解决阿司匹林溶解度差给评价带来的问题,本实验在阿司匹林的0.9%氯化钠注射液中滴加不同pH溶液,并通过磁共振氢谱(hydrogen nuclear magnetic resonance,1HNMR)实验结果证实不同pH条件对阿司匹林结构的影响。结果不同pH条件会不同程度的影响阿司匹林溶解度和结构。1HNMR数据显示,在选择的所有碱性溶液中,只有滴加1%NaHCO3既可以改善其溶解度,又不会破坏阿司匹林的结构。滴加醋酸同样不会破坏阿司匹林的结构。结论1HNMR技术能作为观察药物结构的一种手段,并以此为基础指导相关的生物活性评价。Objective Aspirin as a commonly used antithrombotic drug has low solubility in saline.In this study the effects of different pH on the structure of aspirin were observed by using the 1H nuclear magnetic resonance(1HNMR) technique.Methods In order to improve the solubility of aspirin,the experiments were conducted with adding different alkaline and acidic solution dropwise into the aspirin saline solution until it is completely dissolved,and the effects of different alkaline and acidic solution on the struct...

关 键 词：阿司匹林 药物结构 磁共振氢谱 

分 类 号：R96[医药卫生—药理学]