有序介孔材料SBA-15提高难溶性药物吡咯昔康溶出度的研究  

Improvement of dissolution rate of piroxicam by assembling into SBA-15 mesoporous silica

作　　者：付廷明[1] 乐康[1] 陆瑾[1] 王天瑶[1] 郭立玮[1] 

机构地区：[1]南京中医药大学药学院,江苏南京210094

出　　处：《华西药学杂志》2010年第2期144-146,共3页West China Journal of Pharmaceutical Sciences

基　　金：教育部博士点基金(20060315007);第四十五批中国博士后科学基金(20090451242)

摘　　要：目的采用与介孔材料复合的方式提高难溶性药物吡咯昔康的溶出度。方法通过X射线衍射、氮气吸附-脱附曲线、热分析及溶出度实验,观察吡咯昔康负载到SBA-15的表面情况。结果吡咯昔康溶解后自组装在介孔材料SBA-15的表面,紫外吸收与热重分析表明负载量为17%;X射线衍射、氮气吸附-脱附曲线、热分析及溶出度实验表明:吡咯昔康以极小非晶的形式负载在SBA-15的表面,负载后吡咯昔康的溶出度提高了144%。结论本研究为提高难溶性药物的溶出度提供了一条新途径。OBJECTIVE To improved the dissolution rate of piroxicam.METHODS It was shown that Piroxicam was attached on the surface of SBA-15 through X-ray diffraction,N2 adsorption-desorption isotherms and differential scanning calorimeter experiments.The effect of Piroxicam attached on the surface of SBA-15 was investigated in dissolution experiment.RESULTS Piroxicam was dissolved and self-assembled on the surface of SBA-15 and UV spectrophotometry analysis and gravitational thermal analysis showed that the loading c...

关 键 词：介孔材料 溶出度 吡咯昔康 SBA-15 难溶性药物 

分 类 号：R927.2[医药卫生—药学]